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Exploration of the Enteric Nervous System in Alzheimer Disease
Sponsor: Nantes University Hospital
Summary
The close homology between the central and enteric nervous system suggests that a disease process affecting the central nervous system could also involve its enteric counterpart. This has already been demonstrated for patients with Parkinson's disease but needs to be proven for Alzheimer's disease. Studies on enteric nervous system during Alzheimer's disease are indeed in low number and don't have led to definite conclusion. The investigators thus propose to realize a complete analysis of the enteric nervous systems in Alzheimer's disease by studying the presence of "tau' protein, of beta-amyloid peptide,... not only by immunohistochemical but also by a biochemical approach. This study will be realized from colonic samples.
Official title: Exploration of the Enteric Nervous System in Alzheimer Disease : a Monocentric Pilot Study
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
0
Start Date
2018-04-26
Completion Date
2019-09-18
Last Updated
2026-06-24
Healthy Volunteers
Yes
Conditions
Interventions
biopsies of colon
Removal of additional biopsies of colon during the course of a colonoscopy planned for usual medical follow-up of patient