Clinical Research Directory

Inclusion Criteria: * Age: less than 75 years * The patient must be approved for transplant by the treating transplant physician. This includes completion of their pre-transplant workup, as directed by standard Dartmouth-Hitchcock Medical Center (DHMC) Standard Operating Procedure (SOP) (DHMC SOP - Pre-transplant Evaluation of allogeneic recipient (Appendix). * The patient must have a disease (listed below) with treatment-responsiveness that the treating transplant physician believes will benefit from an allogeneic stem cell transplant. The diseases include: * Acute leukemia - Acute Myeloid Leukemia, Acute Lymphocytic Leukemia * Chronic leukemia - Chronic Myeloid Leukemia, Chronic Lymphocytic Leukemia * Myelodysplasia * Myeloproliferative disorder * Myelofibrosis * Lymphoma - Non-Hodgkin's Lymphoma or Hodgkin's disease * Plasma cell disorder, including myeloma, Waldenstrom's Macroglobulinemia * Donor availability- the patient must have an identified RELATED haplo-identical donor * No Human Immunodeficiency Virus infection or active hepatitis B or C * Eastern Cooperative Oncology Group performance status: 0-2 * Diffusing capacity of carbon monoxide (DLCO) greater than or equal to 40 % predicted * Left ventricular ejection fraction greater than or equal to 40% * Serum bilirubin \< 2x upper limit of normal; transaminases \< 3x normal at the time of transplant * No active or uncontrollable infection * In female, a negative pregnancy test if experiencing menstrual periods * No major organ dysfunction precluding transplantation * No evidence of an active malignancy that would limit the patient's survival to less than 2 years. (If there is any question, the PI can make a decision). Exclusion Criteria: * Psychiatric disorder or a mental deficiency of the patient that is sufficiently severe to make compliance with the treatment unlikely, and making informed consent impossible. * Major anticipated illness or organ failure incompatible with survival from bone marrow transplant. * History of refractory systemic infection DONOR ELIGIBILITY * Human leukocyte antigen (HLA) haplo-identical matched related. * The donor must be healthy and must be willing to serve as a donor, based on standard National Marrow Donor Program (NMDP) guidelines and DHMC SOP - Donor Evaluation (Appendix) * The donor must have no significant co-morbidities that would put the donor at marked increased risk * There is no age restriction for the donor * Informed consent must be signed by donor DONOR EXCLUSION CRITERIA * The NMDP guidelines for exclusion criteria will be used (Appendix). In addition, the following donors are NOT eligible: * Pregnant or lactating donor * HIV or active Hep B or C in the donor * Donor unfit to receive G-CSF and undergo apheresis * A donor with a psychiatric disorder or mental deficiency that makes compliance with the procedure unlikely and informed consent impossible