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EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors
Sponsor: University Hospital, Clermont-Ferrand
Summary
Primary objective : To identify epigenetic dysregulations of in vivo TKI-resisting CML cells Hypothesis : An epigenetic dysregulation is involved in the in vivo survival of a CML cell subclone despite the use of TKIs
Official title: Collection of Biological Resources During Medical Care of Patients With Chronic Myeloid Leukemia (CML) in Chronic Phase for an Epigenetic Study of Leukemic Stem Cells
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2018-02-01
Completion Date
2026-02-01
Last Updated
2024-04-09
Healthy Volunteers
No
Interventions
Collection of blood and bone marrow
Collection of blood and bone marrow in order to identify epigenetic abnormalities and their consequences in surviving CML cells after 3 months of TKI treatment
Locations (16)
CHU Annecy-Genevois
Annecy, France
Institut Bergonié
Bordeaux, France
CHU Caen
Caen, France
CHU Clermont-Ferrand
Clermont-Ferrand, France
CHU Grenoble Alpes
Grenoble, France
CHU Lille
Lille, France
Centre Léon Bérard
Lyon, France
Hospices Civils de Lyon
Lyon, France
CHU Nancy
Nancy, France
CHU Nice
Nice, France
Hôpital Bicêtre
Paris, France
Hôpital Henri Mondor
Paris, France
Hôpital Paul Brousse
Paris, France
Hôpital Saint Louis
Paris, France
CHU Saint-Etienne
Saint-Etienne, France
CHU Versailles
Versailles, France