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Parasitic Ulcer Treatment Trial Pilot
Sponsor: University of California, San Francisco
Summary
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine. After four weeks of therapy, participants will be re-randomized to early corticosteroids, later corticosteroids, or placebo.
Key Details
Gender
All
Age Range
13 Years - Any
Study Type
INTERVENTIONAL
Enrollment
49
Start Date
2018-01-01
Completion Date
2022-11-15
Last Updated
2026-05-07
Healthy Volunteers
No
Conditions
Interventions
Chlorhexidine
1 drop half-hourly for days 1-2, then hourly for days 3-6, then 8 times daily until the 4-week visit
Povidone-Iodine
1 drop half-hourly for days 1-2, then hourly for days 3-6, then 8 times daily until the 4-week visit
Prednisolone Sodium Phosphate
1 drop 4 times daily for weeks 4-9, then 2 times daily for weeks 10-11
Hydroxypropyl Methylcellulose
1 drop 4 times daily for weeks 4-9, then 2 times daily for weeks 10-11
Prednisolone Sodium Phosphate
1 drop 4 times daily for weeks 6-9, then 2 times daily for weeks 10-11
Hydroxypropyl Methylcellulose
1 drop 4 times daily for weeks 4-5
Locations (2)
Aravind Eye Hospital
Coimbatore, Tamil Nadu, India
Aravind Eye Hospital
Madurai, Tamil Nadu, India