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RECRUITING

NCT03486873

PHASE3

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who transition into this extension study. This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase. Each participant will transition to this extension study in one of the following three phases, depending on the study phase they were in at the completion of the parent study. Participants who were in the First Course Phase of study treatment with pembrolizumab or lenvatinib in their parent study will enter the First Course Phase of this study and complete up to 35 doses or more every 3 weeks (Q3W) or 17 doses or more every 6 weeks (Q6W) of study treatment with pembrolizumab or a pembrolizumab-based combination or lenvatinib according to arm assignment. Participants who were in the Follow-up Phase in the parent study (post-treatment or Survival Follow-up Phase) will enter the Survival Follow-up Phase of this study. Participants who were in the Second Course Phase in their parent study will enter Second Course Phase of this study and complete up to 17 doses Q3W or 8 doses Q6W of study treatment with pembrolizumab or a pembrolizumab-based combination according to arm assignment. Any participant originating from a parent trial where crossover to pembrolizumab was permitted upon disease progression may be eligible for 35 doses as Q3W or 17 doses Q6W of pembrolizumab (approximately 2 years), if they progress while on the control arm and pembrolizumab is approved for the indication in the country where the potential eligible crossover participant is being evaluated.

Official title: A Multicenter, Open-label, Phase 3 Study to Evaluate the Long-term Safety and Efficacy in Participants Who Are Currently on Treatment or in Follow-up in Studies That Include Pembrolizumab

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

3500

Start Date

2018-08-21

Completion Date

2043-08-04

Last Updated

2026-04-06

Healthy Volunteers

Conditions

Solid Tumors Hematologic Malignancies

Interventions

DRUG

Pembrolizumab

200 or 400 mg IV infusion

DRUG

Standard of Care (SOC)

IV infusion or oral tablets

DRUG

Lenvatinib

Oral capsules

DRUG

Olaparib

300mg or 250mg or 100mg oral tablers

DRUG

MK-4280

IV Infusion

BIOLOGICAL

MK-4280A

800mg favezelimab + 200mg pembrolizumab IV Infusion

BIOLOGICAL

Pembrolizumab (+) Berahyaluronidase alfa

395 mg or 790 mg SC administration

Inclusion Criteria: * Treated on the parent pembrolizumab studies established by the Sponsor as MK-3475-587 ready. * Currently receiving pembrolizumab, pembrolizumab based combinations or lenvatinib from parent studies or in a follow-up phase. Additional eligibility criteria for participants who enter Second Course Phase once they are enrolled on MK-3475-587: * Has not received any anticancer systemic treatment since the last dose of pembrolizumab or a pembrolizumab-based combination in First Course Phase. * Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Demonstrates adequate organ function. * Have resolution of any toxic effect(s) of First Course Phase trial treatment with pembrolizumab or a pembrolizumab-based combination to Grade 1 or less (except alopecia) before trial treatment in Second Course Phase is started. If participant received major surgery or radiation therapy of \>30 Gray (Gy), they must have recovered from the toxicity and/or complications of the intervention. * A female participant is eligible to enroll if she is not pregnant, not breastfeeding, and ≥1 of the following conditions applies: A woman of childbearing potential (WOCBP) who agrees to use contraception during the study treatment period and for ≥120 days (corresponding to time needed to eliminate any study combination treatment(s) plus 30 days (a menstruation cycle) for study treatments with risk of genotoxicity. Additional eligibility criteria for participants who enter dosing with Lenvatinib: * Adequately controlled blood pressure (BP) to \<150/90 mmHg, with or without antihypertensive medications. * For male agrees to be abstinent from penile-vaginal intercourse OR agrees to use a highly effective contraceptive method while receiving study drug and for 7 days after the last dose of lenvatinib. * Is female and not pregnant/breastfeeding and at least one of the following applies during the study and for ≥4 days after: is not a woman of childbearing potential (WOCBP), is a WOCBP and uses highly effective contraception (low user dependency method OR a user dependent hormonal method in combination with a barrier method) or is a WOCBP who is abstinent from heterosexual intercourse. Exclusion Criteria: -There are no exclusion criteria to participate in MK-3475-587. Participants are excluded from entering Second Course trial treatment once they are enrolled on MK-3475-587 if any of the following criteria applies: * Has severe hypersensitivity (≥ Grade 3) to pembrolizumab and/or any of its excipients. * Has received a live vaccine within 30 days prior to the first dose of Second Course Phase trial treatment. * Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the Cycle 1 Day 1 of Second Course Phase. * Has a known additional malignancy that is progressing or requires active treatment. Exceptions include early stage cancers (carcinoma in situ or Stage 1) treated with curative intent, melanoma (non-ulcerated, thin primary), basal cell carcinoma of the skin, squamous cell carcinoma of the skin, in situ cervical cancer, or in situ breast cancer that has undergone potentially curative therapy. * Has known active central nervous system metastases and/or carcinomatous meningitis. * Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed. * Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis. Note: Participants that experienced pneumonitis during First Course that did not meet the criteria for permanent discontinuation are eligible. * Non-small cell lung cancer (NSCLC) participants only: Has interstitial lung disease. * Has an active infection requiring systemic therapy. * Has a known history of human immunodeficiency virus (HIV) infection. * Has a known history of or is positive for hepatitis B or hepatitis C. For parent studies where inclusion of participants with hepatitis was permitted, MK-3475-587 will follow the parent study eligibility criteria for hepatitis. * Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the Second Course Phase eligibility Visit through 120 days after the last dose of study treatment. * Has severe cardiovascular disease, i.e., arrhythmias, requiring chronic treatment, congestive heart failure (New York Heart Association Class III or IV) or symptomatic ischemic heart disease. * Has hepatic decompensation (Child-Pugh score \>6 \[class B and C\]). * Has uncontrolled thyroid dysfunction. * Has uncontrolled diabetes mellitus. * Has had an allogeneic tissue/solid organ transplant. * Has a known history of active tuberculosis (TB; Bacillus tuberculosis). Additional exclusion criteria for participants who enter dosing with Lenvatinib: * Has had major surgery within 3 weeks prior to first dose of study intervention(s). * Has preexisting ≥Grade 3 gastrointestinal or non-gastrointestinal fistula. * Has urine protein ≥1 g/24 hours. * Has LVEF below the institutional (or local laboratory) normal range, as determined by multigated acquisition scan (MUGA) or echocardiogram (ECHO). * Has radiographic evidence of encasement or invasion of a major blood vessel, or of intratumoral cavitation. * Prolongation of QT intervals corrected for heart rate using Fridericia's (cube root) correction (QTcF) interval to \>480 ms. * Has clinically significant cardiovascular disease within 12 months from first dose of study intervention, including New York Heart Association Class III or IV congestive heart failure, unstable angina, myocardial infarction, cerebral vascular accident, or cardiac arrhythmia associated with hemodynamic instability. * Gastrointestinal malabsorption or any other condition that might affect the absorption of lenvatinib. * Active hemoptysis (bright red blood of at least 0.5 teaspoon) within 3 weeks prior to the first dose of study drug. * Has a history of any contraindication or has a severe hypersensitivity to any components of lenvatinib.

Locations (777)

Arizona Cancer Center at UMC North ( Site 0018)

Tucson, Arizona, United States

Comprehensive Blood & Cancer Center [Bakersfield, CA] ( Site 0054)

Bakersfield, California, United States

California Cancer Associates for Research & Excellence ( Site 0016)

Fresno, California, United States

Providence Medical Foundation ( Site 0087)

Fullerton, California, United States

The Angeles Clinic and Research Institute ( Site 0005)

Los Angeles, California, United States

UCLA Hematology/Oncology - Westwood (Building 100) ( Site 0009)

Los Angeles, California, United States

University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0076)

Orange, California, United States

Stanford Cancer Center ( Site 0086)

Palo Alto, California, United States

UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0004)

San Francisco, California, United States

Providence Saint John's Health Center ( Site 0059)

Santa Monica, California, United States

University of Colorado Cancer Center ( Site 0021)

Aurora, Colorado, United States

Yale Cancer Center ( Site 0014)

New Haven, Connecticut, United States

Georgetown University Medical Center ( Site 0023)

Washington D.C., District of Columbia, United States

Holy Cross Hospital, Michael & Dianne Bienes Comp Cancer Ctr ( Site 0022)

Fort Lauderdale, Florida, United States

Baptist MD Anderson Cancer Center ( Site 0083)

Jacksonville, Florida, United States

Mount Sinai Medical Center Comprehensive Cancer Center ( Site 0031)

Miami Beach, Florida, United States

Moffitt Cancer Center ( Site 0011)

Tampa, Florida, United States

Emory School of Medicine ( Site 0013)

Atlanta, Georgia, United States

Augusta University ( Site 0077)

Augusta, Georgia, United States

Northwest Georgia Oncology Centers PC ( Site 0061)

Marietta, Georgia, United States

Kaiser Permanente Moanalua Medical Center ( Site 0063)

Honolulu, Hawaii, United States

The University of Chicago ( Site 0020)

Chicago, Illinois, United States

University of Iowa Hospital and Clinics ( Site 0026)

Iowa City, Iowa, United States

James Graham Brown Cancer Center ( Site 0058)

Louisville, Kentucky, United States

Mercy Health-Paducah Cancer Center ( Site 0084)

Paducah, Kentucky, United States

Women's Cancer Care ( Site 0088)

Covington, Louisiana, United States

MedStar Franklin Square Medical Center ( Site 0046)

Baltimore, Maryland, United States

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0056)

Baltimore, Maryland, United States

Maryland Oncology Hematology (MOH) ( Site 8000)

Columbia, Maryland, United States

Massachusetts General Hospital ( Site 0041)

Boston, Massachusetts, United States

Dana-Farber Cancer Institute ( Site 0006)

Boston, Massachusetts, United States

Karmanos Cancer Institute ( Site 0047)

Detroit, Michigan, United States

Mayo Clinic in Rochester, Minnesota ( Site 0002)

Rochester, Minnesota, United States

Comprehensive Cancer Centers of Nevada ( Site 0043)

Las Vegas, Nevada, United States

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0038)

Hackensack, New Jersey, United States

Cancer Institute of New Jersey ( Site 0025)

New Brunswick, New Jersey, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0032)

New York, New York, United States

Memorial Sloan Kettering Cancer Center ( Site 0012)

New York, New York, United States

White Plains Hospital-Center for Cancer Care ( Site 0069)

White Plains, New York, United States

WakeMed Cancer Care - Waverly Hematology & Medical Oncology ( Site 0074)

Cary, North Carolina, United States

University of North Carolina at Chapel Hill ( Site 0040)

Chapel Hill, North Carolina, United States

Levine Cancer Institute ( Site 0034)

Charlotte, North Carolina, United States

Duke Cancer Center ( Site 0028)

Durham, North Carolina, United States

Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0065)

Fargo, North Dakota, United States

University Hospitals ( Site 0044)

Cleveland, Ohio, United States

Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0082)

Tulsa, Oklahoma, United States

Providence Portland Medical Center ( Site 0051)

Portland, Oregon, United States

St. Luke's University Health Network ( Site 0017)

Bethlehem, Pennsylvania, United States

University of Pennsylvania ( Site 0010)

Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center ( Site 0042)

Philadelphia, Pennsylvania, United States

UPMC Hillman Cancer Center ( Site 0008)

Pittsburgh, Pennsylvania, United States

Saint Francis Health System ( Site 0089)

Greenville, South Carolina, United States

Sanford Cancer Center ( Site 0066)

Sioux Falls, South Dakota, United States

West Cancer Center and Research Institute ( Site 0055)

Germantown, Tennessee, United States

Vanderbilt Health One Hundred Oaks Diagnostic ( Site 0060)

Nashville, Tennessee, United States

Vanderbilt Ingram Cancer Center ( Site 0015)

Nashville, Tennessee, United States

Texas Oncology - Central/South Texas ( Site 8001)

Austin, Texas, United States

Texas Oncology-Baylor Sammons Cancer Center ( Site 0062)

Dallas, Texas, United States

University of Texas MD Anderson Cancer Center ( Site 0007)

Houston, Texas, United States

South Texas Accelerated Research Therapeutics, LLC (START) ( Site 0001)

San Antonio, Texas, United States

University of Virginia Health System ( Site 0035)

Charlottesville, Virginia, United States

Bon Secours St. Francis Medical Center-Oncology Research ( Site 0075)

Midlothian, Virginia, United States

VCU Health Adult Outpatient Pavillion ( Site 0080)

Richmond, Virginia, United States

Blue Ridge Cancer Care ( Site 0067)

Roanoke, Virginia, United States

Fred Hutchinson Cancer Center ( Site 0024)

Seattle, Washington, United States

Centro de Oncología e Investigación de Buenos Aires ( Site 1357)

Berazategui, Buenos Aires, Argentina

Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 1368)

Buenos Aires., Buenos Aires, Argentina

Fundacion Favaloro ( Site 1367)

CABA, Buenos Aires, Argentina

Derma Internacional SA ( Site 1372)

CABA, Buenos Aires, Argentina

Instituto Alexander Fleming ( Site 1364)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

IDIM - Instituto de Investigaciones Metabólicas ( Site 1362)

Ciudad de Buenos Aires, Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata ( Site 1363)

Mar del Plata, Buenos Aires, Argentina

Instituto Médico Río Cuarto ( Site 1375)

Río Cuarto, Córdoba Province, Argentina

Clinica Viedma ( Site 1353)

Viedma, Río Negro Province, Argentina

Fundacion Estudios Clinicos ( Site 1369)

Rosario, Santa Fe Province, Argentina

Sanatorio Parque ( Site 1355)

Rosario, Santa Fe Province, Argentina

Instituto de Oncologia de Rosario ( Site 1350)

Rosario, Santa Fe Province, Argentina

Hospital Provincial del Centenario ( Site 1359)

Rosario, Santa Fe Province, Argentina

Hospital Aleman-Oncology ( Site 1351)

Buenos Aires, Argentina

Clínica Universitaria Reina Fabiola ( Site 1376)

Córdoba, Argentina

Centro Medico Privado CEMAIC ( Site 1371)

Córdoba, Argentina

Hospital Privado Universitario de Córdoba ( Site 1354)

Córdoba, Argentina

Fundación CORI para la Investigación y Prevención del Cáncer ( Site 1358)

La Rioja, Argentina

Instituto San Marcos ( Site 1366)

San Juan, Argentina

Centro Medico San Roque-Oncology ( Site 1352)

San Miguel de Tucumán, Argentina

Centro Oncologico Norte. ( Site 1370)

Santiago del Estero, Argentina

Chris OBrien Lifehouse ( Site 3003)

Camperdown, New South Wales, Australia

Royal Prince Alfred Hospital-A.W. Morrow Gastroenterology and Liver Centre ( Site 3016)

Camperdown, New South Wales, Australia

Liverpool Hospital-Medical Oncology ( Site 3021)

Liverpool, New South Wales, Australia

Macquarie University ( Site 3010)

Macquarie University, New South Wales, Australia

Mater Hospital Sydney ( Site 3007)

North Sydney, New South Wales, Australia

Orange Hospital-Clinical Trials Unit ( Site 3027)

Orange, New South Wales, Australia

Port Macquarie - Mid North Coast Cancer Institute-Medical Oncology ( Site 3020)

Port Macquarie, New South Wales, Australia

Royal North Shore Hospital-Medical Oncology Clinical Trials ( Site 3025)

St Leonards, New South Wales, Australia

Calvary Mater Newcastle ( Site 3005)

Waratah, New South Wales, Australia

Westmead Hospital ( Site 3000)

Westmead, New South Wales, Australia

Melanoma Institute Australia ( Site 3001)

Wollstonecraft, New South Wales, Australia

Mater Misericordiae Limited-Medical Oncology ( Site 3019)

Brisbane, Queensland, Australia

Gallipoli Medical Research Ltd ( Site 3011)

Brisbane, Queensland, Australia

Royal Brisbane and Women's Hospital ( Site 3009)

Herston, Queensland, Australia

Gold Coast University Hospital ( Site 3028)

Southport, Queensland, Australia

Tasman Oncology Research Pty Ltd ( Site 3012)

Southport, Queensland, Australia

Sunshine Coast University Private Hospital-Coastal Cancer Care ( Site 3032)

Sunshine Coast, Queensland, Australia

The Townsville Hospital ( Site 3017)

Townsville, Queensland, Australia

Princess Alexandra Hospital ( Site 3002)

Woolloongabba, Queensland, Australia

Royal Adelaide Hospital ( Site 3014)

Adelaide, South Australia, Australia

The Queen Elizabeth Hospital ( Site 3026)

Woodville, South Australia, Australia

Monash Health ( Site 3015)

Clayton, Victoria, Australia

Austin Health-Austin Hospital ( Site 3004)

Heidelberg, Victoria, Australia

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3008)

Melbourne, Victoria, Australia

St Vincent's Hospital-Oncology Clinical Trials ( Site 3018)

Melbourne, Victoria, Australia

Western Health-Sunshine & Footscray Hospitals ( Site 3023)

St Albans, Victoria, Australia

Ballarat Oncology & Haematology Services ( Site 3022)

Wendouree, Victoria, Australia

Fiona Stanley Hospital ( Site 3029)

Murdock, Western Australia, Australia

Sir Charles Gairdner Hospital ( Site 3006)

Nedlands, Western Australia, Australia

St John of God Subiaco Hospital ( Site 3013)

Subiaco, Western Australia, Australia

Medical University of Graz ( Site 2952)

Graz, Styria, Austria

Medizinische Universitaet Innsbruck ( Site 2951)

Innsbruck, Tyrol, Austria

Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 2957)

Linz, Upper Austria, Austria

Kepler Universitätsklinikum ( Site 2955)

Linz, Upper Austria, Austria

Uniklinikum Salzburg ( Site 2956)

Salzburg, Austria

Medizinische Universität Wien ( Site 2953)

Vienna, Austria

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2954)

Vienna, Austria

AZ Sint-Maarten ( Site 2904)

Mechelen, Antwerpen, Belgium

Institut Jules Bordet ( Site 2903)

Anderlecht, Bruxelles-Capitale, Region de, Belgium

Cliniques Universitaires de Bruxelles - CUB - Hopital Erasme ( Site 2905)

Brussels, Bruxelles-Capitale, Region de, Belgium

UZ Brussel ( Site 2900)

Brussels, Bruxelles-Capitale, Region de, Belgium

Cliniques universitaires Saint-Luc-Medical Oncology ( Site 2911)

Brussels, Bruxelles-Capitale, Region de, Belgium

AZ Maria Middelares ( Site 2908)

Ghent, Oost-Vlaanderen, Belgium

UZ Leuven ( Site 2901)

Leuven, Vlaams-Brabant, Belgium

UZ Leuven - Campus Gasthuisberg ( Site 2906)

Leuven, Vlaams-Brabant, Belgium

UZ Leuven Gasthuisberg, Gynaecologie-Verloskunde ( Site 2907)

Leuven, Vlaams-Brabant, Belgium

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi ( Site 2909)

Namur, Belgium

Hospital São Carlos-Oncocentro Ce ( Site 1029)

Fortaleza, Ceará, Brazil

CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA-Pesquisa Clínica ( Site 1024)

Fortaleza, Ceará, Brazil

Centro de Pesquisa Clínica do Instituto do Câncer do Ceará ( Site 1016)

Fortaleza, Ceará, Brazil

Hospital Erasto Gaertner ( Site 1036)

Curitiba, Paraná, Brazil

Hospital Tacchini ( Site 1040)

Bento Gonçalves, Rio Grande do Sul, Brazil

ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 1008)

Ijuí, Rio Grande do Sul, Brazil

Hospital de Clínicas de Passo Fundo ( Site 1025)

Passo Fundo, Rio Grande do Sul, Brazil

Lacks - Oncologia E Hematologia ( Site 1026)

Pelotas, Rio Grande do Sul, Brazil

Hospital de Clinicas de Porto Alegre ( Site 1000)

Porto Alegre, Rio Grande do Sul, Brazil

Hospital São Lucas da PUCRS-Centro de Pesquisa em Oncologia ( Site 1006)

Porto Alegre, Rio Grande do Sul, Brazil

Hospital Nossa Senhora da Conceição ( Site 1011)

Porto Alegre, Rio Grande do Sul, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 1035)

Porto Alegree, Rio Grande do Sul, Brazil

Clinica Viver ( Site 1021)

Santa Maria, Rio Grande do Sul, Brazil

Instituto de Oncologia Saint Gallen ( Site 1039)

Ssanta Cruz Do Sul, Rio Grande do Sul, Brazil

CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 1034)

Florianópolis, Santa Catarina, Brazil

CEPON ( Site 1012)

Florianópolis, Santa Catarina, Brazil

Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1041)

Itajaí, Santa Catarina, Brazil

Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1010)

Barretos, São Paulo, Brazil

Hospital Amaral Carvalho ( Site 1023)

Jaú, São Paulo, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site 1003)

São José do Rio Preto, São Paulo, Brazil

Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA ( Site 1017)

São Paulo, São Paulo, Brazil

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA ( Site 1020)

Rio de Janeiro, Brazil

Instituto de de Educação, pesquisa e Gestão em Saúde ( Site 1014)

Rio de Janeiro, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1001)

São Paulo, Brazil

BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 1030)

São Paulo, Brazil

Hospital Paulistano ( Site 1033)

São Paulo, Brazil

A. C. Camargo Cancer Center ( Site 1002)

São Paulo, Brazil

Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 1018)

São Paulo, Brazil

Arthur J.E. Child Comprehensive Cancer Centre ( Site 2815)

Calgary, Alberta, Canada

Cross Cancer Institute ( Site 2804)

Edmonton, Alberta, Canada

CancerCare Manitoba ( Site 2814)

Winnipeg, Manitoba, Canada

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2801)

Hamilton, Ontario, Canada

Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 2808)

Kingston, Ontario, Canada

London Health Sciences Centre ( Site 2806)

London, Ontario, Canada

The Ottawa Hospital - General Campus ( Site 2813)

Ottawa, Ontario, Canada

Sunnybrook Research Institute ( Site 2802)

Toronto, Ontario, Canada

Mount Sinai Hospital ( Site 2811)

Toronto, Ontario, Canada

Princess Margaret Cancer Centre ( Site 2803)

Toronto, Ontario, Canada

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre-Oncology ( Site 2809)

Greenfield Park, Quebec, Canada

Centre Intégré de Santé et de Services Sociaux (CISSS) de La-Centre intégré de cancérologie de Lava ( Site 2810)

Laval, Quebec, Canada

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 2807)

Montreal, Quebec, Canada

Jewish General Hospital ( Site 2800)

Montreal, Quebec, Canada

St. Marys Hospital Center ( Site 2820)

Montreal, Quebec, Canada

McGill University Health Centre ( Site 2818)

Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 2805)

Québec, Quebec, Canada

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 2812)

Sherbrooke, Quebec, Canada

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 2816)

Trois-Rivières, Quebec, Canada

IC La Serena Research ( Site 2766)

La Serena, Coquimbo Region, Chile

UNIVERSIDAD CATÓLICA DEL MAULE ( Site 2768)

Talca, Maule Region, Chile

Centro de Estudios Clínicos SAGA ( Site 2767)

Santiago, Region M. de Santiago, Chile

Orlandi Oncologia-Oncology ( Site 2752)

Santiago, Region M. de Santiago, Chile

Fundacion Arturo Lopez Perez FALP ( Site 2750)

Santiago, Region M. de Santiago, Chile

Oncovida ( Site 2759)

Santiago, Region M. de Santiago, Chile

Clínica Inmunocel ( Site 2762)

Santiago, Region M. de Santiago, Chile

Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 2751)

Santiago, Region M. de Santiago, Chile

Instituto Nacional del Cancer-CR Investigación ( Site 2753)

Santiago, Region M. de Santiago, Chile

Bradfordhill-Clinical Area ( Site 2756)

Santiago, Region M. de Santiago, Chile

James Lind Centro de Investigacion del Cancer ( Site 2757)

Temuco, Región de la Araucanía, Chile

CIDO SpA ( Site 2765)

Temuco, Región de la Araucanía, Chile

ONCOCENTRO APYS-ACEREY ( Site 2758)

Viña del Mar, Región de Valparaíso, Chile

Centro de Investigaciones ( Site 2755)

Viña del Mar, Región de Valparaíso, Chile

Biocenter ( Site 2763)

Concepción, Región del Biobío, Chile

Bradford Hill Norte ( Site 2761)

Antofagasta, Chile

Anhui Provincial Hospital-Cancer Chemotherapy Department ( Site 3480)

Hefei, Anhui, China

Anhui Provincil Hospital South District-Respiratory Medicine Dept ( Site 3487)

Hefei, Anhui, China

Beijing Cancer Hospital ( Site 3451)

Beijing, Beijing Municipality, China

The Fifth Medical Center Of The Chinese PLA General Hospital (South) ( Site 3465)

Beijing, Beijing Municipality, China

Beijing Cancer Hospital ( Site 3499)

Beijing, Beijing Municipality, China

Beijing Cancer Hospital ( Site 3500)

Beijing, Beijing Municipality, China

Beijing Cancer hospital-Thoracic Cancer Department A ( Site 3454)

Beijing, Beijing Municipality, China

Chinese Academy of medical science, Peking Union Medical College Hospital(Dongdan) ( Site 3466)

Beijing, Beijing Municipality, China

Army Medical Center of People's Liberation Army-Oncology Department ( Site 3477)

Chongqing, Chongqing Municipality, China

Fujian Provincial Cancer Hospital ( Site 3461)

Fuzhou, Fujian, China

The First Affiliated Hospital of Xiamen University ( Site 3514)

Xiamen, Fujian, China

Southern medical university Nangfang Hospital ( Site 3490)

Guanghzou, Guangdong, China

The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 3491)

Guangzhou, Guangdong, China

SUN YAT-SEN UNIVERSITY CANCER CENTRE-Internal Medicine ( Site 3452)

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center-melanoma ( Site 3482)

Guangzhou, Guangdong, China

Guangdong Provincial People's Hospital-Cancer Center ( Site 3462)

Guangzhou, Guangdong, China

The First Affiliated Hospital, Sun Yat-sen University-pneumology department ( Site 3459)

Guangzhou, Guangdong, China

The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 3460)

Guangzhou, Guangdong, China

Nanfang Hospital of Southern Medical University ( Site 3509)

Guangzhou, Guangdong, China

The Affiliated Cancer Hospital of Guizhou Medical University ( Site 3498)

Guiyang, Guizhou, China

Fourth Hospital of Hebei Medical University ( Site 3520)

Shijiazhuang, Hebei, China

Harbin Medical University Cancer Hospital ( Site 3506)

Harbin, Heilongjiang, China

Harbin Medical University Cancer Hospital-Harbin Medical University Cancer Hospital ( Site 3475)

Harbin, Heilongjiang, China

Henan Cancer Hospital ( Site 3488)

Zhengzhou, Henan, China

Tongji Hospital Tongji Medical,Science & Technology-oncology ( Site 3476)

Wuhan, Hubei, China

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 3492)

Wuhan, Hubei, China

Xiangya Hospital Central South University ( Site 3508)

Changsha, Hunan, China

Xiangya Hospital Central South University-Gynecology ( Site 3497)

Changsha, Hunan, China

Xiangya Hospital Central South University-Respiratory ( Site 3479)

Changsha, Hunan, China

Hunan Cancer Hospital ( Site 3485)

Changsha, Hunan, China

Hunan Cancer Hospital ( Site 3501)

Changsha, Hunan, China

Jiangsu Cancer Hospital-Medical Oncotherapy ( Site 3469)

Nanjing, Jiangsu, China

Yancheng First People s Hospital ( Site 3504)

Yancheng, Jiangsu, China

Northern Jiangsu People's Hospital-General Surgery Department ( Site 3474)

Yangzhou, Jiangsu, China

The First Affiliated Hospital of Nanchang University ( Site 3513)

Nanchang, Jiangxi, China

The First Hospital of Jilin University-Oncology ( Site 3464)

Changchun, Jilin, China

Jilin Province Tumor Hospital ( Site 3484)

Changchun, Jilin, China

Tangdu Hospital of Fourth Military Medical University of Chi-department of radiotherapy ( Site 3455)

Xi'an, Shaanxi, China

Shandong Cancer Hospital ( Site 3517)

Jinan, Shandong, China

LinYi Cancer Hospital ( Site 3511)

Linyi, Shandong, China

Fudan University Shanghai Cancer Center ( Site 3467)

Shanghai, Shanghai Municipality, China

Zhongshan Hospital of Fudan University ( Site 3503)

Shanghai, Shanghai Municipality, China

Obstetrics & Gynecology Hospital of Fudan University ( Site 3494)

Shanghai, Shanghai Municipality, China

Shanghai Pulmonary Hospital ( Site 3470)

Shanghai, Shanghai Municipality, China

The First Affiliated Hospital of Xi an Jiaotong University ( Site 3489)

XiAn, Shanxi, China

West China Hospital Sichuan University-respiratory ( Site 3473)

Chengdu, Sichuan, China

Sichuan Cancer hospital. ( Site 3515)

Chengdu, Sichuan, China

The Second People's Hospital of Yibin ( Site 3516)

Yibin, Sichuan, China

Tianjin Medical University Cancer Institute and Hospital ( Site 3456)

Tianjin, Tianjin Municipality, China

Xinjiang Medical University Cancer Hospital - Urumqi-galactophore department ( Site 3486)

Ürümqi, Xinjiang, China

The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 3502)

Ürümqi, Xinjiang, China

Women s Hospital School of Medicine Zhejiang University ( Site 3493)

Hangzhou, Zhejiang, China

Hangzhou Cancer Hospital-Medical Oncology ( Site 3468)

Hangzhou, Zhejiang, China

The First Affiliated Hospital of Zhejiang University ( Site 3518)

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital ( Site 3495)

Hangzhou, Zhejiang, China

Sir Run Run Shaw Hospital ( Site 3505)

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital ( Site 3481)

Hangzhou, Zhejiang, China

Instituto de Cancerología-Oncology ( Site 2702)

Medellín, Antioquia, Colombia

Fundacion Colombiana de Cancerología Clinica Vida ( Site 2707)

Medellín, Antioquia, Colombia

Clinica de la Costa S.A.S. ( Site 2705)

Barranquilla, Atlántico, Colombia

Administradora Country S.A. ( Site 2701)

Bogotá, Bogota D.C., Colombia

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2704)

Valledupar, Cesar Department, Colombia

Instituto Nacional De Cancerologia-Oncología Clínica ( Site 2706)

Bogota, Cundinamarca, Colombia

IMAT S.A.S ( Site 2703)

Montería, Departamento de Córdoba, Colombia

Oncologos del Occidente ( Site 2709)

Pereira, Risaralda Department, Colombia

Fundación Valle del Lili ( Site 2700)

Cali, Valle del Cauca Department, Colombia

Clínica Imbanaco S.A.S ( Site 2708)

Cali, Valle del Cauca Department, Colombia

Hospital Metropolitano - Sede Lindora ( Site 3901)

Santa Ana, Provincia de San José, Costa Rica

CIMCA ( Site 3900)

San José, Costa Rica

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0703)

Brno, Brno-mesto, Czechia

Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0704)

Olomouc, Olomoucký kraj, Czechia

Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 0702)

Prague, Praha 4, Czechia

Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0705)

Prague, Praha 5, Czechia

Fakultni nemocnice Olomouc ( Site 0701)

Olomouc, Czechia

Fakultni nemocnice v Motole ( Site 0700)

Prague, Czechia

Odense Universitetshospital ( Site 0650)

Odense, Region Syddanmark, Denmark

Vejle Sygehus ( Site 0653)

Vejle, Region Syddanmark, Denmark

Tartu University Hospital-Radiotherapy and oncology ( Site 3800)

Tartu, Tartu, Estonia

Tampere University Hospital [Tampere Finland] ( Site 0600)

Tampere, Pirkanmaa, Finland

Turku University Hospital ( Site 0601)

Turku, Southwest Finland, Finland

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Dermatology Department ( Site 2539)

Nice, Alpes-Maritimes, France

Nouvel Hôpital Civil (NHC) ( Site 2529)

Strasbourg, Alsace, France

CHU Bordeaux Haut-Leveque ( Site 2534)

Pessac, Aquitaine, France

CH Lyon Sud Hospices Civils de Lyon ( Site 2521)

Pierre-Bénite, Auvergne-Rhône-Alpes, France

Centre Hopitalar Leon-Berard ( Site 2519)

Lyon, Auvergne, France

Hopital Nord ( Site 2516)

Marseille, Bouches-du-Rhone, France

Hôpital Privé Clairval ( Site 2549)

Marseille, Bouches-du-Rhone, France

CHU La Timone ( Site 2508)

Marseille, Bouches-du-Rhone, France

Centre Francois Baclesse ( Site 2558)

Caen, Calvados, France

Centre Georges François Leclerc-Centre de recherche clinique ( Site 2536)

Dijon, Cote-d Or, France

CHU-Jean Minjoz ( Site 2550)

Besançon, Doubs, France

CHU Jean Minjoz ( Site 2520)

Besançon, Doubs, France

CHRU Brest - Hopital Cavale Blanche ( Site 2504)

Brest, Finistere, France

Institut Bergonie ( Site 2502)

Bordeaux, Gironde, France

CHU Toulouse - Hopital Rangueil ( Site 2518)

Toulouse, Haute-Garonne, France

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE ( Site 2560)

Toulouse, Haute-Garonne, France

CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 2526)

Toulouse, Haute-Garonne, France

Centre Hospitalier Annecy Genevois ( Site 2554)

Epagny Metz Tessy, Haute-Savoie, France

Centre Oscar Lambret ( Site 2551)

Lille, Hauts-de-France, France

Ambroise Pare Hopital ( Site 2503)

Boulogne, Hauts-de-Seine, France

Hôpital Foch ( Site 2543)

Suresnes, Hauts-de-Seine, France

CHU Montpellier. ( Site 2556)

Montpellier, Herault, France

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 2525)

Rennes, Ille-et-Vilaine, France

Hopital Trousseau ( Site 2512)

Chambray-lès-Tours, Indre-et-Loire, France

C.H.U. de Tours - Hopital Bretonneau ( Site 2515)

Tours, Indre-et-Loire, France

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes-lung oncology ( Site 2546)

Saint-Herblain, Loire-Atlantique, France

Institut de Cancérologie de l'Ouest-Oncologie Médicale ( Site 2522)

Saint-Herblain, Loire-Atlantique, France

Institut de Cancérologie de Lorraine Alexis Vautrin ( Site 2532)

Vandœuvre-lès-Nancy, Lorraine, France

CHRU Lille Hospital Claude Huriez ( Site 2506)

Lille, Nord, France

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 2542)

Clermont-Ferrand, Puy-de-Dome, France

Centre Hospitalier de Pau ( Site 2563)

Pau, Pyrenees-Atlantiques, France

C.H.U. Pontchaillou ( Site 2511)

Pierre-Bénite, Rhone, France

Centre Hospitalier du Mans-Pneumologie ( Site 2527)

Le Mans, Sarthe, France

Centre Henri Becquerel ( Site 2547)

Rouen, Seine-Maritime, France

Hôpital Avicenne-Dermatologie ( Site 2538)

Bobigny, Seine-Saint-Denis, France

Clinique de L'Europe ( Site 2548)

Amiens, Somme, France

Centre Hopitalier Intercommunal Creteil ( Site 2514)

Créteil, Val-de-Marne, France

HENRI MONDOR HOSPITAL ( Site 2561)

Créteil, Val-de-Marne, France

Hôpital Universitaire Paul Brousse ( Site 2541)

Villejuif, Val-de-Marne, France

Institut Sainte Catherine ( Site 2557)

Avignon, Vaucluse, France

Centre Hospitalier Universitaire de Poitiers-Dermatologie ( Site 2544)

Poitiers, Vienne, France

Hopital Cochin ( Site 2509)

Paris, France

Hopital Saint Louis ( Site 2510)

Paris, France

CHU Hopital Saint Antoine ( Site 2517)

Paris, France

Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 2545)

Paris, France

Hôpital Tenon ( Site 2530)

Paris, France

Hôpital Beaujon ( Site 2524)

Clichy, Île-de-France Region, France

Groupe hospitalier Paris saint Joseph-Service de Pneumologie-Allergologie -Oncologie Thoracique ( Site 2533)

Paris, Île-de-France Region, France

Institut Gustave Roussy ( Site 2513)

Villejuif, Île-de-France Region, France

Universitaetsklinikum Tuebingen ( Site 2405)

Tübingen, Baden-Wurttemberg, Germany

Universitätsklinikum Erlangen ( Site 2408)

Erlangen, Bavaria, Germany

Universitaetsklinik Muenchen ( Site 2406)

Munich, Bavaria, Germany

Krankenhaus Nordwest ( Site 2409)

Frankfurt am Main, Hesse, Germany

Elbe Klinikum Buxtehude ( Site 2400)

Buxtehude, Lower Saxony, Germany

Medizinische Hochschule Hannover ( Site 2402)

Hanover, Lower Saxony, Germany

Universitaetsklinikum Essen ( Site 2404)

Essen, North Rhine-Westphalia, Germany

Universitaetsklinikum des Saarlandes-Klinik für Innere Medizin V-Pneumologie, Allergologie, Beatmun ( Site 2411)

Homburg, Saarland, Germany

Universitatsklinikum Carl Gustav Carus ( Site 2407)

Dresden, Saxony, Germany

LungenClinic Grosshansdorf GmbH ( Site 2412)

Großhansdorf, Schleswig-Holstein, Germany

SRH Wald-Klinikum Gera GmbH ( Site 2403)

Gera, Thuringia, Germany

Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 2418)

Berlin, Germany

Facharztzentrum Eppendorf ( Site 2415)

Hamburg, Germany

General Hospital of Athens "Laiko"-Hematology Department ( Site 1851)

Athens, Attica, Greece

Sotiria Regional Chest Diseases Hospital of Athens ( Site 1850)

Athens, Attica, Greece

Andreas Syggros Hospital ( Site 1853)

Athens, Attica, Greece

European Interbalkan Medical Center ( Site 1855)

Thessaloniki, Greece

MEDI-K ( Site 3403)

Guatemala City, Guatemala

CELAN,S.A ( Site 3405)

Guatemala City, Guatemala

Oncomedica ( Site 3401)

Guatemala City, Guatemala

Grupo Medico Angeles ( Site 3402)

Guatemala City, Guatemala

Queen Mary Hospital ( Site 1902)

Hksar, Hong Kong

Queen Mary Hospital-Department of Medicine (Respiratory) ( Site 1900)

Hksar, Hong Kong

Princess Margaret Hospital ( Site 1903)

Hong Kong, Hong Kong

Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Megyei Onkológiai Centrum ( Site 1405)

Gyula, Bekes County, Hungary

Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház ( Site 1409)

Miskolc, Borsod-Abauj Zemplen county, Hungary

Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 1419)

Kecskemét, Bács-Kiskun county, Hungary

Fejér Megyei Szent György Egyetemi Oktató Kórház-l.Pulmonologia ( Site 1407)

Székesfehérvár, Fejér, Hungary

Petz Aladar Egyetemi Oktato Korhaz-Pulmonológia (Dr. Szalai Zsuzsanna) ( Site 1408)

Győr, Győr-Moson-Sopron, Hungary

Mátrai Gyógyintézet ( Site 1417)

Gyöngyös, Heves County, Hungary

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1401)

Szolnok, Jász-Nagykun-Szolnok, Hungary

Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1411)

Budapest, Pest County, Hungary

Reformatus Pulmonologiai Centrum ( Site 1418)

Törökbálint, Pest County, Hungary

Markusovszky Egyetemi Oktatokorhaz-Onkológiai Osztály ( Site 1410)

Szombathely, Vas County, Hungary

Farkasgyepui Tudogyogyintezet-Pulmonologia ( Site 1414)

Farkasgyepű, Veszprém megye, Hungary

Semmelweis University-Belgyógyászati és Hematológiai Klinika ( Site 1406)

Budapest, Hungary

Orszagos Koranyi Pulmonologiai Intezet ( Site 1403)

Budapest, Hungary

Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 1413)

Budapest, Hungary

Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 1415)

Debrecen, Hungary

Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 1412)

Debrecen, Hungary

Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1402)

Kaposvár, Hungary

Zala Megyei Szent Rafael Korhaz ( Site 1400)

Zalaegerszeg, Hungary

Mater Misercordiae University Hospital ( Site 1800)

Dublin, Leinster, Ireland

Tallaght University Hospital ( Site 1803)

Dublin, Ireland

St. James s Hospital ( Site 1801)

Dublin, Ireland

Emek Medical Center ( Site 2072)

Afula, Israel

Rambam Health Care Campus-Oncology Division ( Site 2053)

Haifa, Israel

Bnai Zion Medical Center ( Site 2060)

Haifa, Israel

Shaare Zedek Medical Center ( Site 2068)

Jerusalem, Israel

Hadassah Ein Kerem Medical Center ( Site 2051)

Jerusalem, Israel

Rabin Medical Center ( Site 2059)

Petah Tikva, Israel

Chaim Sheba Medical Center. ( Site 2052)

Ramat Gan, Israel

Chaim Sheba Medical Center ( Site 2055)

Ramat Gan, Israel

Sheba Medical Center ( Site 2062)

Ramat Gan, Israel

Sheba Medical Center ( Site 2065)

Ramat Gan, Israel

ZIV Medical Center-Hematology Institute ( Site 2061)

Safed, Israel

Sourasky Medical Center ( Site 2054)

Tel Aviv, Israel

Shamir Medical Center Assaf Harofeh ( Site 2058)

Ẕerifin, Israel

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1978)

Bologna, Emilia-Romagna, Italy

Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 1963)

Rome, Lazio, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1975)

Rome, Lazio, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1977)

Milan, Lombardy, Italy

Azienda Ospedaliera San Gerardo ( Site 1980)

Monza, Lombardy, Italy

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1968)

Rozzano, Milano, Italy

IRCCS CRO Aviano, Hematology/Oncology ( Site 1957)

Aviano, Pordenone, Italy

Ospedale Cannizzaro ( Site 1981)

Catania, Sicily, Italy

Istituto di Candiolo - IRCCS ( Site 1960)

Candiolo, Torino, Italy

Ospedale San Luigi Gonzaga ( Site 1956)

Orbassano, Torino, Italy

AO Santa Maria della Misericordia-Oncology Department ( Site 1971)

Perugia, Umbria, Italy

Istituto Oncologico Veneto IRCCS ( Site 1976)

Padova, Veneto, Italy

Humanitas Gavazzeni ( Site 1954)

Bergamo, Italy

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-UOC Oncologia ( Site 1967)

Bergamo, Italy

Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1972)

Brescia, Italy

IRCCS A.O.U. San Martino - IST ( Site 1961)

Genova, Italy

Ospedale San Raffaele. ( Site 1979)

Milan, Italy

Istituto Europeo di Oncologia ( Site 1952)

Milan, Italy

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1955)

Naples, Italy

Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 1964)

Parma, Italy

Fondazione IRCCS Policlinico San Matteo ( Site 1982)

Pavia, Italy

Azienda Ospedaliera San Camillo Forlanini ( Site 1958)

Roma, Italy

Policlinico Universitario Agostino Gemelli ( Site 1965)

Roma, Italy

ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 1969)

Siena, Italy

Azienda Ospedaliera Santa Maria ( Site 1962)

Terni, Italy

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1974)

Torino, Italy

National Hospital Organization Nagoya Medical Center ( Site 3109)

Nagoya, Aichi-ken, Japan

Aichi Cancer Center ( Site 3101)

Nagoya, Aichi-ken, Japan

Nagoya University Hospital ( Site 3151)

Nagoya, Aichi-ken, Japan

National Cancer Center Hospital East ( Site 3121)

Kashiwa, Chiba, Japan

National Hospital Organization Shikoku Cancer Center ( Site 3116)

Matsuyama, Ehime, Japan

Ehime University Hospital ( Site 3158)

Tōon, Ehime, Japan

Kurume University Hospital ( Site 3105)

Kurume, Fukuoka, Japan

National Hospital Organization Hokkaido Cancer Center ( Site 3160)

Sapporo, Hokkaido, Japan

Sapporo Kosei General Hospital ( Site 3172)

Sapporo, Hokkaido, Japan

Sapporo Medical University Hospital ( Site 3113)

Sapporo, Hokkaido, Japan

Hokkaido University Hospital ( Site 3165)

Sapporo, Hokkaido, Japan

Hyogo Cancer Center ( Site 3131)

Akashi, Hyōgo, Japan

National Hospital Organization Himeji Medical Center ( Site 3111)

Himeji, Hyōgo, Japan

Kobe City Medical Center General Hospital ( Site 3144)

Kobe, Hyōgo, Japan

Hyogo Medical University Hospital ( Site 3100)

Nishinomiya, Hyōgo, Japan

Ibaraki Prefectural Central Hospital ( Site 3180)

Kasama, Ibaraki, Japan

University of Tsukuba Hospital ( Site 3176)

Tsukuba, Ibaraki, Japan

Kanazawa University Hospital ( Site 3140)

Kanazawa, Ishikawa-ken, Japan

Iwate Medical University Hospital ( Site 3157)

Shiwa-gun, Iwate, Japan

Kagawa University Hospital ( Site 3171)

Kita, Kagawa-ken, Japan

Nippon Medical School Musashi Kosugi Hospital ( Site 3178)

Kawasaki, Kanagawa, Japan

St. Marianna University Hospital ( Site 3182)

Kawasaki, Kanagawa, Japan

Kitasato University Hospital ( Site 3142)

Sagamihara, Kanagawa, Japan

Yokohama City University Hospital ( Site 3163)

Yokohama, Kanagawa, Japan

Kanagawa Cancer Center ( Site 3137)

Yokohama, Kanagawa, Japan

Yokosuka Kyosai Hospital ( Site 3150)

Yokosuka, Kanagawa, Japan

Miyagi Cancer Center ( Site 3122)

Natori-shi, Miyagi, Japan

Tohoku University Hospital ( Site 3175)

Sendai, Miyagi, Japan

Sendai Kousei Hospital ( Site 3115)

Sendai, Miyagi, Japan

Nara Medical University Hospital ( Site 3110)

Kashihara, Nara, Japan

Niigata Cancer Center Hospital ( Site 3173)

Niigata, Niigata, Japan

Kurashiki Central Hospital ( Site 3132)

Kurashiki, Okayama-ken, Japan

University of the Ryukyus Hospital ( Site 3155)

Ginowan, Okinawa, Japan

Osaka Habikino Medical Center ( Site 3138)

Habikino, Osaka, Japan

Kansai Medical University Hospital ( Site 3126)

Hirakata, Osaka, Japan

Kindai University Hospital ( Site 3102)

Sakai, Osaka, Japan

Kindai University Hospital ( Site 3135)

Sakai, Osaka, Japan

Kindai University Hospital ( Site 3166)

Sakai, Osaka, Japan

Osaka Rosai Hospital ( Site 3148)

Sakai, Osaka, Japan

The University of Osaka Hospital ( Site 3168)

Suita, Osaka, Japan

Osaka Medical and Pharmaceutical University Hospital ( Site 3167)

Takatsuki, Osaka, Japan

Osaka Medical and Pharmaceutical University Hospital ( Site 3187)

Takatsuki, Osaka, Japan

Saitama Medical University International Medical Center ( Site 3118)

Hidaka, Saitama, Japan

Saitama Prefectural Cancer Center ( Site 3112)

Kitaadachi-gun, Saitama, Japan

Dokkyo Medical University Saitama Medical Center ( Site 3152)

Koshigaya, Saitama, Japan

National Defense Medical College Hospital ( Site 3177)

Tokorozawa, Saitama, Japan

Shizuoka Cancer Center ( Site 3128)

Nakatogari, Shizuoka, Japan

Jichi Medical University Hospital ( Site 3141)

Shimotsuke, Tochigi, Japan

Institute of Science Tokyo Hospital ( Site 3149)

Bunkyō, Tokyo, Japan

Cancer Institute Hospital of JFCR ( Site 3146)

Koto, Tokyo, Japan

Cancer Institute Hospital of JFCR ( Site 3164)

Koto, Tokyo, Japan

Toranomon Hospital ( Site 3134)

Minato-ku, Tokyo, Japan

Toranomon Hospital ( Site 3153)

Minato-ku, Tokyo, Japan

Kyorin University Hospital ( Site 3103)

Mitaka, Tokyo, Japan

Kyorin University Hospital ( Site 3147)

Mitaka-shi, Tokyo, Japan

Tokyo Medical University Hospital ( Site 3170)

Shinjuku-ku, Tokyo, Japan

National Hospital Organization Yamaguchi Ube Medical Center ( Site 3123)

Ube, Yamaguchi, Japan

Yamaguchi University Hospital ( Site 3114)

Ube, Yamaguchi, Japan

Chiba Cancer Center ( Site 3117)

Chiba, Japan

National Hospital Organization Kyushu Medical Center ( Site 3136)

Fukuoka, Japan

National Hospital Organization Kyushu Cancer Center ( Site 3169)

Fukuoka, Japan

Kyushu University Hospital ( Site 3143)

Fukuoka, Japan

Kyushu University Hospital ( Site 3185)

Fukuoka, Japan

Gifu University Hospital ( Site 3161)

Gifu, Japan

Hiroshima City Hiroshima Citizens Hospital ( Site 3119)

Hiroshima, Japan

Hiroshima University Hospital ( Site 3154)

Hiroshima, Japan

Kochi Health Sciences Center ( Site 3145)

Kochi, Japan

Kumamoto University Hospital ( Site 3179)

Kumamoto, Japan

Kyoto University Hospital ( Site 3181)

Kyoto, Japan

Niigata University Medical & Dental Hospital ( Site 3174)

Niigata, Japan

Okayama University Hospital ( Site 3107)

Okayama, Japan

Osaka City General Hospital ( Site 3125)

Osaka, Japan

National Hospital Organization Osaka National Hospital ( Site 3162)

Osaka, Japan

Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 3129)

Osaka, Japan

Osaka General Medical Center ( Site 3184)

Osaka, Japan

National Cancer Center Hospital ( Site 3130)

Tokyo, Japan

St.Luke's International Hospital ( Site 3120)

Tokyo, Japan

The Jikei University Hospital ( Site 3156)

Tokyo, Japan

Nippon Medical School Hospital ( Site 3139)

Tokyo, Japan

Tokyo Metropolitan Komagome Hospital ( Site 3133)

Tokyo, Japan

Cancer Institute Hospital of JFCR ( Site 3108)

Tokyo, Japan

Keio University Hospital ( Site 3127)

Tokyo, Japan

Teikyo University Hospital ( Site 3104)

Tokyo, Japan

Toyama Prefectural Central Hospital ( Site 3183)

Toyama, Japan

Wakayama Medical University Hospital ( Site 3124)

Wakayama, Japan

Liepjas reionl slimnca ( Site 3851)

Liepāja, Latvia

RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia-Out-patient and Day patient facility of Ch ( Site 3850)

Riga, Latvia

Klaipeda University Hospital-Oncology chemotherapy ( Site 3302)

Klaipėda, Klaipedos Miestas, Lithuania

Vilniaus Universiteto Ligonine Santaros Klinikos ( Site 3300)

Vilnius, Lithuania

Vilnius University Hospital Santaros Clinics Affiliate - National Cancer Center ( Site 3301)

Vilnius, Lithuania

Hospital Tengku Ampuan Afzan ( Site 0627)

Kuantan, Pahang, Malaysia

Gleneagles Penang ( Site 0625)

George Town, Pulau Pinang, Malaysia

Hospital Pulau Pinang ( Site 0629)

George Town, Pulau Pinang, Malaysia

Institut Kanser Negara - National Cancer Institute ( Site 0630)

Putrajaya - Wilayah Persekutuan, Putrajaya, Malaysia

Pantai Hospital Kuala Lumpur ( Site 0628)

Kuala Lumpur, Malaysia

University Malaya Medical Centre ( Site 0626)

Kuala Lumpur, Malaysia

Investigación Oncofarmacéutica-Investigación clínica ( Site 1114)

La Paz, Baja California Sur, Mexico

Centro de Inmuno Oncología de Occidente SA de CV ( Site 1115)

Guadalajara, Jalisco, Mexico

Arke Estudios Clinicos ( Site 1117)

Mexico City, Mexico City, Mexico

INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1102)

Mexico City, Mexico City, Mexico

Avix Investigación Clinica, S.C.-Oncology ( Site 1104)

Monterrey, Nuevo León, Mexico

I Can Oncology Center SA de CV ( Site 1116)

Monterrey, Nuevo León, Mexico

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Hematologia and Oncologia ( Site 1113)

Monterrey, Nuevo León, Mexico

Centro de Urologa Avanzada del Noreste ( Site 1110)

San Pedro Garza García, Nuevo León, Mexico

Oaxaca Site Management Organization ( Site 1106)

Oaxaca City, Oaxaca, Mexico

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C. ( Site 1119)

Ciudad Madero, Tamaulipas, Mexico

Medical Care and Research SA de CV ( Site 1103)

Mérida, Yucatán, Mexico

Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 1109)

Chihuahua City, Mexico

Oncare Viaducto Napoles ( Site 1107)

Mexico City, Mexico

Cuidados Oncologicos. ( Site 1118)

Querétaro, Mexico

Radboud University Medical Center ( Site 1554)

Nijmegen, Gelderland, Netherlands

Antoni van Leeuwenhoek Ziekenhuis ( Site 1551)

Amsterdam, North Holland, Netherlands

Amsterdam UMC, locatie VUmc ( Site 1555)

Amsterdam, North Holland, Netherlands

Erasmus MC ( Site 1553)

Rotterdam, South Holland, Netherlands

Universitair Medisch Centrum Groningen ( Site 1550)

Groningen, Netherlands

Canterbury Regional Cancer & Blood Service ( Site 1500)

Christchurch, Canterbury, New Zealand

Palmerston North Hospital, MidCentral DHB ( Site 1504)

Palmerston North, Manawatu-Wanganui, New Zealand

Waikato Hospital ( Site 1502)

Hamilton, Waikato Region, New Zealand

Auckland City Hospital ( Site 1503)

Auckland, New Zealand

Capital & Coast District Health Board - Wellington Hospital ( Site 1501)

Wellington, New Zealand

Helse Bergen Haukeland universitetssykehus ( Site 1451)

Bergen, Vestfold, Norway

Oslo Universitetssykehus Radiumhospitalet ( Site 1450)

Oslo, Norway

Oslo universitetssykehus, Radiumhospitalet ( Site 1452)

Oslo, Norway

IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0678)

Lima, Peru

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0681)

Lima, Peru

Hospital Cayetano Heredia-Oncology ( Site 0675)

Lima, Peru

Makati Medical Center ( Site 1702)

Makati City, National Capital Region, Philippines

Lung Center of the Philippines ( Site 1705)

Quezon City, National Capital Region, Philippines

St. Luke s Medical Center ( Site 1700)

Quezon City, National Capital Region, Philippines

Przychodnia Lekarska KOMED ( Site 1603)

Konin, Greater Poland Voivodeship, Poland

Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 1607)

Poznan, Greater Poland Voivodeship, Poland

Med-Polonia Sp. z o. o. ( Site 1605)

Poznan, Greater Poland Voivodeship, Poland

Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna ( Site 1601)

Poznan, Greater Poland Voivodeship, Poland

Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 1619)

Poznan, Greater Poland Voivodeship, Poland

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1612)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Oddzial w Krakowie ( Site 1608)

Krakow, Lesser Poland Voivodeship, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1618)

Krakow, Lesser Poland Voivodeship, Poland

Luxmed Onkologia sp. z o. o. ( Site 1621)

Warsaw, Masovian Voivodeship, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 1604)

Warsaw, Masovian Voivodeship, Poland

Wojskowy Instytut Medyczny-Klinika Onkologii ( Site 1606)

Warsaw, Masovian Voivodeship, Poland

Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Kosza-Klinika Onkologii z Odcinkiem Dziennym ( Site 1616)

Opole, Opole Voivodeship, Poland

Bialostockie Centrum Onkologii ( Site 1610)

Bialystok, Podlaskie Voivodeship, Poland

Uniwersyteckie Centrum Kliniczne-Klinika Chirurgii Onkologicznej, Transplantacyjnej i Ogólnej ( Site 1622)

Gdansk, Pomeranian Voivodeship, Poland

Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1625)

Gdynia, Pomeranian Voivodeship, Poland

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1620)

Gliwice, Silesian Voivodeship, Poland

Szpital Rejonowy im. dr. J. Rostka w Raciborzu ( Site 1624)

Racibórz, Silesian Voivodeship, Poland

Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 1623)

Olsztyn, Warmian-Masurian Voivodeship, Poland

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie ( Site 1614)

Koszalin, West Pomeranian Voivodeship, Poland

Powiatowe Centrum Zdrowia w Brzezinach Sp. z o. o. Oddział Dziennej Chemioterapii ( Site 1611)

Brzeziny, Łódź Voivodeship, Poland

Instytut Centrum Zdrowia Matki Polki-Klinika Onkologii ( Site 1609)

Lodz, Łódź Voivodeship, Poland

Champalimaud Foundation ( Site 1751)

Lisbon, Lisbon District, Portugal

Unidade Local de Saude de Santa Maria - Hospital Pulido Valente ( Site 1750)

Lisbon, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil, EPE-Oncologia Médica ( Site 1753)

Porto, Portugal

Centro Hospitalar de Sao Joao - Hospital de Sao Joao ( Site 1752)

Porto, Portugal

Ad-Vance Medical Research-Research ( Site 1151)

Ponce, Puerto Rico

FDI Clinical Research ( Site 1152)

San Juan, Puerto Rico

UPR Comprehensive Cancer Center ( Site 1150)

San Juan, Puerto Rico

MEMORIAL HEALTHCARE INTERNATIONAL S.R.L ( Site 3553)

Bucharest, București, Romania

Cardiomed SRL Cluj-Napoca ( Site 3555)

Cluj-Napoca, Cluj, Romania

Centrul de Oncologie "Sfântul Nectarie" ( Site 3552)

Craiova, Dolj, Romania

Cabinet Medical Oncomed ( Site 3554)

Timișoara, Timiș County, Romania

Institutul Oncologic "Prof. Dr. Ioan Chiricuta" ( Site 3551)

Cluj-Napoca, Romania

Spitalul Județean Sfântul Ioan cel Nou Suceava-Oncology ( Site 3550)

Suceava, Romania

Altai Regional Clinical Oncology Center ( Site 1229)

Barnaul, Altayskiy Kray, Russia

GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 1250)

Ufa, Baskortostan, Respublika, Russia

Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1204)

Ufa, Baskortostan, Respublika, Russia

Bashkir State Medical University ( Site 1221)

Ufa, Baskortostan, Respublika, Russia

Belgorod Oncology Dispensary ( Site 1213)

Belgorod, Belgorod Oblast, Russia

LLC Medical Centre "Lotos" ( Site 1253)

Chelyabinsk, Chelyabinsk Oblast, Russia

Regional Budgetary Healthcare Institution 'Ivanovo Regional Oncology Dispensary'-Urology ( Site 1219)

Ivanovo, Ivanovo Oblast, Russia

Oncological Dispensary #2 of Ministry of Health of Krasnodar region ( Site 1244)

Sochi, Krasnodarskiy Kray, Russia

GBUZ LOKB ( Site 1218)

Saint-Petersburg, Leningradskaya Oblast', Russia

GBUZ LOKB-Oncology department #1 ( Site 1222)

Saint-Petersburg, Leningradskaya Oblast', Russia

Ogarev Mordovia State University ( Site 1206)

Saransk, Mordoviya, Respublika, Russia

The National Medico-Surgical Center N.I. Pirogov ( Site 1225)

Moscow, Moscow, Russia

N.N. Blokhin NMRCO ( Site 1209)

Moscow, Moscow, Russia

Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1201)

Moscow, Moscow, Russia

FSBI-FRCC of Special Types Med. Care and Technologies FMBA of Russia ( Site 1234)

Moscow, Moscow, Russia

Russian Scientific Center of Roentgenoradiology ( Site 1215)

Moscow, Moscow, Russia

First Moscow State Medical University n.a. I.M.Sechenov ( Site 1245)

Moscow, Moscow, Russia

P. A. Hertsen Moscow Oncology Research Center ( Site 1214)

Moscow, Moscow, Russia

P. A. Hertsen Moscow Oncology Research Center ( Site 1247)

Moscow, Moscow, Russia

FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 1208)

Moscow, Moscow, Russia

Volga District Medical Center Federal Medical and Biological Agency ( Site 1242)

Nizhny Novgorod, Nizhny Novgorod Oblast, Russia

Russian Scientific Research Institute of Hematology and Blood Transfusion-Hematology ( Site 1224)