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Glutathione in Mild Cognitive Impairment
Sponsor: Baylor College of Medicine
Summary
Elderly humans have an increased risk of dementia which begins as mild defects in memory called mild cognitive impairment. Glutathione (GSH), a key endogenous antioxidant has been linked to cognition. This exploratory study will investigate mechanisms linked to GSH for cognitive impairment (and improvement) by studying humans with mild cognitive impairment who will be evaluated 12-weeks after receiving either N-acetylcysteine and glycine (GSH precursors), or receiving alanine, and a further 12-weeks after stopping these supplements.
Key Details
Gender
All
Age Range
55 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2018-04-19
Completion Date
2026-12-31
Last Updated
2026-03-24
Healthy Volunteers
No
Conditions
Interventions
Glycine
Dietary Supplement: glycine will be supplemented in the active arm for 12-weeks
N-acetylcysteine (NAC)
Dietary Supplement: NAC will be supplemented in the active arm for 12-weeks
Alanine
Dietary Supplement: Alanine will be supplemented in the placebo arm for 12-weeks
Locations (1)
Baylor College of Medicine
Houston, Texas, United States