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Prediction of ARrhythmic Events With Positron Emission Tomography II
Sponsor: State University of New York at Buffalo
Summary
Sudden cardiac death continues to be a major contributor to mortality in patients with ischemic cardiomyopathy. While implantable defibrillators can prevent death from ventricular arrhythmias, our current approach to identify patients at highest risk primarily rests on demonstrating a reduction in left ventricular ejection fraction less than 35%. The purpose of this observational cohort study is to prospectively test whether this can be enhanced by quantifying the amount of sympathetic denervation, left ventricular end-diastolic volume or brain natriuretic peptide levels.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
302
Start Date
2018-04-08
Completion Date
2026-12-31
Last Updated
2026-03-06
Healthy Volunteers
No
Interventions
PET scan quantifying sympathetic denervation using [18F]-LMI1195
A cardiac PET scan will be obtained to quantify the percentage of the left ventricle that is denervated and has reduced uptake of the sympathetic nerve tracer \[18F\]-LMI1195
Locations (1)
University at Buffalo Clinical and Translational Research Center
Buffalo, New York, United States