Clinical Research Directory

Inclusion Criteria: * Age \> or = 18 years * Performance status: ECOG \<3 * Diagnosis of acute myeloid leukemia or acute lymphoblastic leukemia candidate to intensive chemotherapy * Indication to allogeneic Hematopoietic stem cell transplantation (HSCT) for hematological cancers, including severe aplastic anemia (second transplants allowed) * Pre-treatment colonization by Carbapenem-resistant Enterobacteriaceae (CRE) or Pseudomonas aeruginosa (PA) documented by rectal and/or pharyngeal swab. * Pre-treatment bloodstream infection sustained by CRE or PA. * Written and signed informed consent Exclusion Criteria: * Uncontrolled systemic infection * Anaphylaxis or severe prior reactions to immunoglobulins preparation * Severe concomitant illness: * patients with severe renal impairment, i.e. patients on dialysis or prior renal transplantation or S-creatinine \> 3.0 x ULN or calculated (CKD-EPI) creatinine-clearance \< 50 ml/min * patients with severe pulmonary impairment (DLCOSB (Hb-adjusted)/or FEV1 \< 50 % or severe dyspnea at rest or requiring oxygen supply); * patients with severe cardiac impairment (LVEF \< 40 %) * patients with severe hepatic impairment (hyperbilirubinemia \> 3 x ULN or ALT / AST \> 5 x ULN). * patients who on the basis of the investigator's consideration are not able to give the informed consent