Clinical Research Directory

Inclusion Criteria: * Males and females ≥ 18 years of age. * Ability to understand the nature of the proposed surgical procedure and sign an informed consent form. * ASA I and ASA II. * In need of an implant in the posterior region of the maxilla, * RBH of \<4 mm or RBH \>4 mm but no transcrestal approach possible (due to anatomy). * Healthy oral mucosa and no active periodontal disease. * Edentulous sites consisting of native, non-augmented bone. Exclusion Criteria: * General contraindications for implant placement and/or surgical treatment. * Acute infection or residual lesions in the edentulous sites. * Acute maxillary sinus pathosis. * Ongoing inflammatory and/or autoimmune diseases of the oral cavity. * Patients with poor oral hygiene who are not amenable to improvement. * Immunosuppressants, corticosteroids, or bisphosphonate * History of malignancy, radiotherapy, or chemotherapy for malignancy within the past five years. * Smoker \> 10 cigarettes. * Uncontrolled insulin-dependent diabetes. * Pregnant or lactating women. * Alcohol and drug abuse.