Clinical Research Directory

Inclusion Criteria: * Patients males and females ≥ 18 years old * Patients providing a written informed consent in English language * Patients scheduled to undergo rhinoplasty under general endotracheal anesthesia Exclusion Criteria: 1. Patients with known allergies to medications described in this study: acetaminophen, gabapentin, and opioids (morphine, fentanyl, hydromorphone, oxycodone) 2. Patients with chronic use of opioids due to any medical/surgical condition or those receiving any opioid medication within the 48 hours before surgery 3. Use of gabapentin and/or pregabalin within the last 14 days prior to surgery 4. Use of acetaminophen within the last 7 days prior to surgery 5. Hepatic disease as documented in patient past medical history 6. Medical history of autoimmune/neurodegenerative disease 7. Pregnancy or breast feeding 8. Patients with history of alcohol or substance abuse/dependency within the last 6 months 9. Patients with previous participation in this study or receiving any investigational product within the last 30 days 10. Patients under legal protection or prisoners