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UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
Sponsor: University of Alabama at Birmingham
Summary
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer \[C-11\]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with \[C-11\]PiB-PET, and cognitive status will be the primary outcome of this imaging study.
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2018-04-20
Completion Date
2028-10
Last Updated
2025-12-11
Healthy Volunteers
Yes
Conditions
Interventions
[C-11]PiB-PET/MRI
All study participants will undergo brain imaging with \[C-11\]PiB-PET/MRI. \[C-11\]PiB is a PET imaging agent used primarily to measure the amount of abnormal protein (called beta-amyloid) in the brain. The investigator will also use this tracer to evaluate regional cerebral blood flow.
Locations (1)
University of Alabama at Birmingham Medical Center
Birmingham, Alabama, United States