Clinical Research Directory

Inclusion Criteria: 1. Age: ≥ 18 years old 2. Patient has been recommended for ablation or recommended for an alternative to surgery 3. Non-small cell lung cancer tumor(s) ≤ 2cm (T1aN0, T1bN0) OR Metastatic lung tumor(s) ≤ 2cm 4. Microscopic proof of malignancy obtained 5. Location of tumor: 1. In periphery of lung (outermost 1/3) 2. Maximum of three vapor ablation applications would target entire margin according to the vapor ablation plan 6. Signed patient informed consent Exclusion Criteria: 1. Centralized tumor (abutting main stem bronchus, main pulmonary artery branches, esophagus, or trachea) 2. Carcinoid lung tumors 3. Tumor is associated with atelectasis or obstructive pneumonitis or pleural effusion 4. Pulmonary function tests (PFTs): post-bronchodilator forced expired volume in one second (FEV1) \<20% predicted, diffusing capacity of the lung for carbon monoxide (DLCO)\<20% predicted 5. Requirement for supplemental oxygen (includes at rest or during exercise) 6. Hospitalization for cardiac disease within the preceding 6 months 7. Liver enzymes (ALP, ALT, AST) or total bilirubin \> 1.5 upper limit of normal (ULN) 8. Serum creatinine \> 2 mg/dl 9. Recent infection (within 30 days) 10. Currently receiving immunosuppressive medication or prednisone \> 10 mg/day (or equivalent) 11. Pre-existing implants within the airways that impede navigation to the target lesion 12. Pregnant or breastfeeding women and those of childbearing potential who are not practicing a reliable form of contraception. 13. Disorder of coagulation, history of severe hemoptysis, or receiving anticoagulant medication. Antiplatelet medication is permitted provided that the medication can be held a minimum of 7 days prior to the procedure and 10 days post-procedure. 14. Any condition that in the opinion of the investigator or reviewer may interfere with the safety of the patient or evaluation of the study objectives 15. Any tumor characteristic that in the opinion of the investigator or reviewers may interfere with the safety of the patient or evaluation of the study objectives.