Clinical Research Directory

Inclusion Criteria: * Males or females aged superior to 35 years * Current or previous smokers (smoked more than 10 packs year) or alcohol drinkers (current or previous, more than 140 g alcohol per week) or both * Histologically proven invasive HNSCC stage 0 to IVa, excluding T4b and nasopharynx. Patients with in situ carcinoma are eligible. * Treated with curative intent * Free of cancer at the post-treatment clinical and radiological examination (negative PET-CT for N≥2) at least 2 months after the end of the last treatment and no later than 4 months after. If there is a strong doubt of lack of complete remission (for example if more exams or longer follow-up are needed to affirm or deny complete remission), the patient is not eligible for the trial. * Remark: Patients with several head and neck squamous cell carcinoma (concomitant or successive), all treated with curative intent and all in complete remission, are eligible. * Agree to have a long term follow-up * Signed informed consent * Patient affiliated to a social security system or beneficiary of the same Exclusion Criteria: * Pregnant or breastfeeding women * Severe psychiatric condition that may inhibit protocol participation and in the judgment of the investigator would make the patient inappropriate for entry into this study. * Impossibility to perform the planned exams of the intensive strategy * Nasopharyngeal carcinoma * Other malignancies within 5 years prior to randomization that needs followup by PET-scan or chest CT or head and neck CT/MRI * Any disease that needs follow-up by regular upper digestive endoscopy