Clinical Research Directory

Inclusion Criteria: 1. Age: 0-18 years, male and female. 2. Any organ system symptoms consistent with the diagnostic points of respiratory monogenic diseases. 3. Agree to retain specimens related to disease research and agree to store the specimens in the sample bank. 4. willing and able to cooperate with long-term follow-up. 5. The guardian of the child has a full understanding of the purpose of the study, a basic understanding of the clinical research program, and voluntarily allows the child to participate in the study and sign an informed consent form. Exclusion Criteria: 1. It is unable to provide complete medical records or the current condition can not accept the diagnosis process 2. She or he cannot agree to participate in the study.