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p16Ink4a in Bronchopulmonary Dysplasia in Children
Sponsor: Centre Hospitalier Intercommunal Creteil
Summary
The bronchopulmonary dysplasia (BPD) is a respiratory disease of the premature child which lead to a reduction of gas exchange surface and to a prolonged respiratory failure. This disease has morphologic and functional consequences at adulthood and is today considered to be an early determinant of respiratory diseases at adulthood. The physiopathology of BPD is not well known. Several mechanisms could be involved especially a reparation failure favored by an increase of cellular senescence which is a permanent stop of cellular proliferation. The transcription factor 16 Ink4a, considered as a marker of aging, is one of the essential markers of senescence. Its increase during prematurity was shown at the blood cells of the cordon, but its involvement in BPD and its evolution in child are not yet studied.
Official title: Case-control Study Evaluating the Impact of p16Ink4a in Bronchopulmonary Dysplasia in Children
Key Details
Gender
All
Age Range
Any - 15 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2018-03-07
Completion Date
2023-12-30
Last Updated
2026-06-15
Healthy Volunteers
No
Conditions
Interventions
Blood punction
For the arms "Term newborns (≥37GA)" and "Premature newborns" the only intervention is a blood punction on the cordon. For the arms "Child between 7 and 15 years old" with or without BPD the only intervention is a blood punction on peripheral blood.
Locations (1)
Centre Hospitalier Intercommunal de Créteil
Créteil, France