Inclusion Criteria:
Three different cohorts of patients with esophageal cancer are studied.
All of the following conditions must apply to the prospective patient at screening prior to receiving study treatment or any study related procedures (e.g.):
* Age \> 18 years
* Patients should have previously untreated histologically proven squamous cell carcinoma or adenocarcinoma of the esophagus or the gastroesophageal junction (GEJ), Siewert I, II or III
* Must be ambulatory with a performance status ECOG 0 or 1
* Adequate organ function based on clinical examination and lab values as defined in the below:
Absolute neutrophil count: ≥ 1,5 x109/L Platelets: ≥ 100 x109/L Hemoglobin: ≥ 9 x109/L Creatinine ≤ 1,5 upper limit normal (ULN) OR measured/calculated GFR≥60 mL/min Albumin ≥ 30 g/L Total bilirubin ≤ 1,5 ULN ASAT and ALAT ≤ 2,5 ULN, or ≤ 5 ULN for subjects with liver mets. International Normalized Ratio (INR) ≤ 1,5 ULN and Activated Partial Thromboplastin Time (TT) ≤ 1,5 ULN unless subject is receiving anticoagulant therapy. Such therapy (if indicated) should be converted to adequate therapy with low-molecular weight heparin such as Dalteparin before chemotherapy or treatment with IMP.
* Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 28 days prior to the start of study drug (screening phase). Women must not be breastfeeding.
* WOCBP should use highly effective adequate method to avoid pregnancy for 23 weeks (30 days plus the time required for Nivolumab to undergo five half-lives) after the last dose of investigational drug. Adequate methods are described in Appendix I.
* Males who are sexually active with WOCBP must agree to follow instructions for method(s) of contraception during the study treatment period and until 7 months after last dose of Nivolumab (see Appendix I).
* Signed informed consent and expected cooperation of the patients for the treatment and follow up must be obtained and documented according to ICH GCP, and national/local regulations.
* If Dysphagia score \>2, a nasogastric feeding tube should be inserted during the aid of gastroscopy, and nasogastric tube feeding started before radiotherapy.
* In addition, specific criteria are defined for the three different patient cohorts below:
Specific inclusion criteria - Cohort A
* Eligible for palliative fractionated radiotherapy of the esophageal- or gastroesophageal cancer as determined by the multidisciplinary team (MDT) meeting.
* Expected survival \>3 months
* Not bulky disease, i.e. palliative radiotherapy towards the primary tumor is intended to palliate dysphagia and/or pain and systemic treatment could be delayed to AFTER protocol therapy if possible.
Specific inclusion criteria - Cohort B
* Eligible for definitive chemoradiation of localized but inoperable esophageal- or gastroesophageal cancer as determined by the multidisciplinary team (MDT) meeting.
* Regional disease, i.e. no metastasis outside the radiation field (PTV).
* Considered candidate/ able to adhere to the intended chemoradiotherapy
Specific inclusion criteria - Cohort C
* Eligible for neoadjuvant chemoradiotherapy and surgery of the esophageal- or gastroesophageal cancer as determined by the multidisciplinary team (MDT) meeting.
* Regional disease, i.e. no metastasis outside the radiation field (PTV).
* Considered candidate and able to adhere to the intended neoadjuvant chemoradiotherapy and planned surgery.
Exclusion Criteria:
Patients will be excluded from the study if they meet any of the following criteria:
* Previous treatment with radiotherapy towards volumes within the thoracic cavity
* Previous treatment with any PD-1 or PD-L1/2 inhibitor
* Hypersensitivity to the investigational product or any of the drug formula contents
* Esophageal stenting
* T4b if infiltration into the aorta or the trachea
* History of prior autoimmune disorders requiring systemic therapy (excluding Insulin or Thyroid replacement therapy)
* History of HIV 1 /2, Hepatitis B or C infection
* History of Immunodeficiency disorders (i.e. immunoglobulin deficiency or white blood cell lineage depletion disorders)
* Participation in any other interventional clinical trial with an investigational product
* History of prior malignancy within the last 5 years, excluding curatively treated basal cell or squamous cell carcinoma of the skin.
* Known history of brain metastases
* Need to use immunosuppressive drugs including, but not limited to: Glucocorticoids, everolimus, sirolimus, disease-modifying anti-rheumatic drugs (DMARDS)
* Positive pregnancy test (positive hCG blood test)
* Known allergy, hypersensitivity, or contraindication to the investigational product Nivolumab, or the drugs paclitaxel and docetaxel used in the standard chemoradiotherapy protocols (Cohorts B and C) or any components used in their preparation or has a contraindication to taxane therapy.
* Any reason why, in the opinion of the investigator, the patient should not participate.
