Clinical Research Directory

Inclusion Criteria: 1. Men and women, aged 18 to 88 years 2. Chronic foot drop and ankle weakness in one leg from a peripheral nervous system injury due to a neuromuscular or orthopedic injury 3. Ability to walk 10 meters and arise from a chair with no human assistance (but usage of usual assistive device\[s\] is permitted) Exclusion Criteria: 1. Cardiac history of (a) unstable angina; (b) recent (less than 3 months) myocardial infarction, congestive heart failure (NYHA category II); and/or (c) hemodynamically significant valvular dysfunction 2. Hypertension that is a contraindication for a bout of walking training (greater than 160/100 mmHg on two assessments) 3. Medical history of (a) recent hospitalization (less than 3 months) for severe medical disease; (b) symptomatic peripheral arterial occlusive disease; (c) orthopedic or chronic pain conditions that significantly alter gait function; (d) pulmonary or renal failure; and/or (e) active cancer 4. Current participation in orthopedic or rehabilitation medical programs 5. Active deep venous thrombosis 6. Distal paretic leg skin lesions, infections, or soft tissue inflammation