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Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Sponsor: Barzilai Medical Center
Summary
Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients. Metoclopramide belongs to the antiemetic group, used for motion sickness and during early gestation for hyperemesis gravidarum. The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation and result in increased oocyte retrival.
Official title: Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients: a Randomised, Double-blind, Placebo-controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 54 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2021-05-05
Completion Date
2028-07
Last Updated
2025-02-10
Healthy Volunteers
Yes
Conditions
Interventions
Metoclopramide
Metoclopramide 10 mg BID
Placebo Oral Tablet
Placebo 10 mg BID
Locations (1)
Barzilai University Medical Center
Ashkelon, Ashkelon District, Israel