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A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer
Sponsor: University of Florida
Summary
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes \[quality of life (QOL), toxicity, and disease control\] between parallel cohorts of men with prostate cancer treated simultaneously at proton therapy facilities and at geographically similar conventional (photon-based) radiation facilities using intensity-modulated radiation therapy (IMRT) techniques.
Key Details
Gender
MALE
Age Range
30 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
3000
Start Date
2018-07-05
Completion Date
2027-07-01
Last Updated
2026-03-09
Healthy Volunteers
No
Conditions
Interventions
Standard of Care IMRT (Photon)
As this trial is pragmatic, all treatment will be standard of care.
Standard of Care Proton Therapy
As this trial is pragmatic, all treatment will be standard of care.
Proton Arm 1: Standard Proton Therapy
78.0 Gy (RBE) in 39 fractions
Proton Arm 2: Hypofractionated Proton Therapy
60.0 Gy (RBE) in 20 fractions
Locations (53)
University of Alabama at Birmingham (UAB)
Birmingham, Alabama, United States
University of California San Diego
La Jolla, California, United States
Proton Therapy Treatment Center - Loma Linda University
Loma Linda, California, United States
Sutter Health
Roseville, California, United States
California Protons Cancer Therapy Center
San Diego, California, United States
Department of Radiation Oncology Davis Cancer Pavilion
Gainesville, Florida, United States
University of Florida Proton Therapy Institute
Jacksonville, Florida, United States
Ackerman Cancer Center
Jacksonville, Florida, United States
Mayo Clinic
Jacksonville, Florida, United States
University of Miami School of Medicine
Miami, Florida, United States
Miami Cancer Institute
Miami, Florida, United States
Orlando Health UF Health Center
Orlando, Florida, United States
Winship Cancer Institute - Emory University
Atlanta, Georgia, United States
University of Chicago
Chicago, Illinois, United States
Northwestern Medicine Proton Center
Warrenville, Illinois, United States
University of Kansas Medical Center
Lawrence, Kansas, United States
University of Louisville
Louisville, Kentucky, United States
Willis-Knighton Medical Center PTC
Shreveport, Louisiana, United States
Johns Hopkins University
Baltimore, Maryland, United States
University of Maryland
College Park, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Karmanos Cancer Institute
Detroit, Michigan, United States
Mayo Clinic Health System
Mankato, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
S Lee Kling Proton Therapy Center - Washington University Medical Center
St Louis, Missouri, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Covenant Health
Somerset, New Jersey, United States
New York Proton Center
New York, New York, United States
Weill Cornell
New York, New York, United States
The Duke University Health System
Durham, North Carolina, United States
UNC- Rex Hospital
Raleigh, North Carolina, United States
University of Cincinnati Medical PTC
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
University Hospitals- Seidman Cancer Center
Cleveland, Ohio, United States
Stephenson Cancer Center
Oklahoma City, Oklahoma, United States
Oregon Health & Science University
Portland, Oregon, United States
University of Pennsylvania--Penn Medicine
Philadelphia, Pennsylvania, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Covenant Health Proton Center
Knoxville, Tennessee, United States
Texas Oncology
Austin, Texas, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Texas Center for Proton Therapy
Irving, Texas, United States
Texas Oncology - Longview
Longview, Texas, United States
Texas Oncology - McKinney
McKinney, Texas, United States
Texas Oncology - Plano West
Plano, Texas, United States
Texas Oncology - Waco
Waco, Texas, United States
University of Virginia
Charlottesville, Virginia, United States
Inova Schar Cancer Institute
Fairfax, Virginia, United States
Hampton University Proton Therapy Institute
Hampton, Virginia, United States
Seattle Care Alliance/University of Washington
Seattle, Washington, United States
Mayo Clinic Health System
Eau Claire, Wisconsin, United States
Mayo Clinic Health System-Franciscan Healthcare
Sparta, Wisconsin, United States