Clinical Research Directory

Inclusion Criteria: * Adults (over 18) * Diagnosis of traumatic brain injury * Expected to survive * Expected to require greater than 24 hours of sedation and mechanical ventilation Exclusion Criteria: * Brain injury thought to be unsurvivable by ICU clinical team * Frontal decompressive craniectomy * Use of ketamine infusion at recruitment or planned use within 24 hours * Fractured frontal bone or severe overlying soft tissue injury * Simple extradural haemorrhage with no other obvious intracranial injury * Pregnant patient