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CONsciousness Transcranial Electric STimulation
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Summary
The aim of this study is to investigate the effect of transcranial Alternating Current Stimulation (tACS) at theta frequency and the the effect of transcranial Direct Current Stimulation (tDCS) on the conscious state of non-communicating patients. tACS and tDCS are non-invasive stimulation techniques that are used to induce brain oscillations at certain frequency or to increase the brain activity in applied region. Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of consciousness and functional communication in some Minimally Conscious State (MCS) patients, and in some Vegetative State (VS) patients. However the optimal intensity of electrical current stimulation remains unknown and transcranial Alternative Current Stimulation (tACS), with the ability to stimulate cortex at specific frequencies and to manipulate phase-synchrony between regions is a promising techniques to improve patients' consciousness. In this study, the investigators will use prefrontal tDCS and theta tACS to improve patients consciousness level.
Official title: Effect of Transcranial Electrical Stimulation on the Consciousness of Non-communicating Patients.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2018-11-19
Completion Date
2024-01-03
Last Updated
2026-09-23
Healthy Volunteers
No
Conditions
Interventions
In-phase 6 Hz prefronto-parietal tACS
tACS is a non-invasive stimulation technique that works by delivering a weak sinusoidally oscillating electrical current to the surface of the skull to entrain oscillations in the brain.
Sham prefronto-parietal tACS
tACS is a non-invasive stimulation technique that works by delivering a weak sinusoidally oscillating electrical current to the surface of the skull to entrain oscillations in the brain.
2 mA left prefrontal tDCS
tDCS is a form of neuromodulation method where very low levels of constant current are delivered to specifically targeted areas of the brain
Sham left prefrontal tDCS
tDCS is a form of neuromodulation method where very low levels of constant current are delivered to specifically targeted areas of the brain
Locations (1)
Institut du Cerveau et de la Moelle - CR-ICM U 975 / UMRS INSERM 1127
Paris, France