Clinical Research Directory

Inclusion Criteria: * Adult patients who are referred to the department of Pulmonary medicine with clinical history suspected of having penicillin allergy. * The control group will be healthy adult volunteers with no history of any personal or family history of drug allergy, atopy, inflammatory or autoimmune diseases. Exclusion Criteria: * Systemic reactions such as DRESS, any internal organ involvement * Clinical history of Type II-III hypersensitivity reaction * Severe Type IV hypersensitivity reaction such as Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, vasculitis, acute generalized exanthematous pustulosis * Chronic idiopathic urticaria on antihistamine maintenance treatment/anti-IgE treatment * Medication which can affect the test outcome * Active signs of an underlying disease such as uncontrolled asthma * Cardiac disease with increased risk of serious anaphylaxis * Pregnancy/Breastfeeding * Reaction within the last 4-6 weeks