Clinical Research Directory

Inclusion Criteria: * Diagnosis of locally advanced cancer (defined as metastatic or recurrent cancer or completed 2 lines of therapy) with fatigue \>= 4/10 (0-10 scale) on the Edmonton Symptom Assessment Scale (ESAS) * Presence of fatigue for at least 2 weeks * Normal cognition defined as Memorial Delirium Assessment Scale (MDAS) of =\< 13/30 completed in person or via video conference * Hemoglobin \> 8 g/L within 2 weeks of enrollment in the study * Zubrod performance status =\< 2 * Life expectancy of \>= 4 months * Able to read, write, and speak English Exclusion Criteria: * Patients with a history of hypersensitivity to dexamethasone or having any contraindication to physical activity as determined by the treating physician * Reports of a fall in the past 30 days * Uncontrolled diabetes mellitus as defined by a random blood sugar of \> 200 mg/dl not being monitored by their primary care physician * Sepsis and/or acute, chronic, or ongoing infections that are currently being treated with systemic antimicrobials * Current, active peptic ulcer disease * Neutropenia as defined by an absolute neutrophil count (ANC) of \< 1000 cells/mm * Regular participation in moderate- or vigorous-intensity physical activity for \>= 30 minutes at least 5 times a week and strength training for \>= 2 days * Symptomatic cardiac disease (New York Heart Association functional class III or IV) or coronary artery disease * Patients currently on immunotherapy * Inability to comply with study protocol procedures