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Adiposity and Endothelin Receptor Function
Sponsor: Augusta University
Summary
Elevated levels of ET-1 have been implicated in cardiovascular disease and some forms of hypertension. Due to the strong, positive correlation between obesity and hypertension, the present study will explore the contribution of adiposity in ETB receptor function and aim to elucidate if ETB receptor dysfunction is a major contributor to hypertension in obesity.
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2018-05-21
Completion Date
2026-01
Last Updated
2025-02-06
Healthy Volunteers
Yes
Conditions
Interventions
Candesartan
7 days of Candesartan (16mg/day)
Placebo
7 days of Placebo
Locations (1)
Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology
Augusta, Georgia, United States