Clinical Research Directory

Inclusion Criteria * Are between the ages of 18-75 years * Have clinical indications for whole sural nerve biopsy * Have a sural nerve SNAP with amplitude \> or = 2 microvolt (μV) * Are able to comply with protocol requirements * Can provide written informed consent * Willingness to complete study procedures Exclusion Criteria * Current smoker. * History of prior musculoskeletal (joint or soft tissue) infection. * Pre-operative nares culture positive for methicillin-resistant Staphylococcus Aureus (MRSA) or methicillin-sensitive Staphylococcus Aureus (MSSA) * Have systemic immune disorders, such as Crohn's Disease, rheumatoid arthritis, or psoriasis with the exception of hyper/hypothyroidism. * Have diabetes mellitus. * Have previous trauma to the biopsy site. * Have any major, clinically significant medical condition (e.g., within six months of baseline, had myocardial infarction, angina pectoris, and/or congestive heart failure) that, in the opinion of the investigator, would compromise the safety of patient. * Are pregnant or breast-feeding. * Unwilling to use adequate contraception.