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Noninvasive Markers of Functional Nausea in Children
Sponsor: Vanderbilt University Medical Center
Summary
The researchers propose to study how functional nausea in adolescents may be characterized noninvasively by the use of multichannel electrogastrogram (EGG) and magnetogastrogram (MGG) recordings.
Key Details
Gender
All
Age Range
8 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2018-08-03
Completion Date
2026-08-31
Last Updated
2025-05-30
Healthy Volunteers
Yes
Conditions
Interventions
Questionnaires
Patients will be provide answers to one or more of the following: Rome III criteria, BARF pictorial scale, Nausea Severity scale, Children's Somatization Inventory, State-Trait Anxiety Inventory, Functional Disability Inventory, and the Nausea Interference Scale.
4 channel electrogastrogram (EGG)
EGG is a non-invasive technique for recording gastric myoelectrical activity using cutaneous electrodes placed on the abdominal skin over the stomach.
36 channel high resolution electrogastrogram (HR-EGG)
HR- EGG utilizes an array of electrodes to estimate the direction and speed of gastric slow-waves using cutaneous electrodes placed on the abdominal skin over the stomach.
Magnetogastrogram (MGG)
MGG measures spatiotemporal properties of magnetic fields from the gastric slow wave and allows characterization of the propagation of the gastric slow wave in addition to evaluation of its frequency and power distribution.
Electrocardiogram (EKG)
Electrocardiography is the process of recording the electrical activity of the heart over a period of time using electrodes placed on the skin
Ondansetron
Patients will be administered 4mg or 8 mg ondansetron dependent upon age in order to assess the effect of ondansetron on the symptoms of nausea and changes in slow wave dysrhythmias.
Cyproheptadine Oral Tablet
Patients will be prescribed a 5 day maintenance dose of cyproheptadine using dosing 4mg twice a day to examine the effects of pharmacological alteration of specific nausea pathways on gastric slow wave patterns in functional nausea patients
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States