Clinical Research Directory

Inclusion Criteria: * For Patients and Controls : * Adult patient, male and female, age 18 to 45 * Patient affiliated with health insurance coverage, * Patient who signed a free and informed consent after receiving detailed, understandable and honest information, * For patients only : * Patient with relapsing-remitting multiple sclerosis according to the McDonald 2010 criteria * Disease duration of less than 5 years * Patients treated or not treated with first-line disease modifying therapy * Detection of at least one post-Gadolinium injection active lesion identified on the initial brain MRI (T0) Exclusion Criteria: * For patients only : • Patients with a progressive form of MS other than the early relapsing-remitting form (primary progressive or secondary progressive) * For Patients and Controls : * Patients with the usual contraindications for MRI (pacemaker, agitation, metal shards, claustrophobia) * Patients at risk of non-compliance to the exam: basic problems with understanding, confusion, involuntary movements, poor tolerance of prolonged supine position * Patients who are unable to give their consent: problems with understanding, lack of vigilance, confusion * Woman who is pregnant and breastfeeding * Patients with a history of neurological or psychiatric condition * Patients under guardianship or trusteeship