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A Study to Evaluate Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis (Measure Up 2)
Sponsor: AbbVie
Summary
The objective of this study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.
Official title: A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects With Moderate to Severe Atopic Dermatitis
Key Details
Gender
All
Age Range
12 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
912
Start Date
2018-07-27
Completion Date
2025-11-11
Last Updated
2026-06-02
Healthy Volunteers
No
Conditions
Interventions
Placebo for Upadacitinib
Tablets taken orally once a day
Upadacitinib
Tablets taken orally once a day
Locations (196)
Total Skin and Beauty Derm Ctr /ID# 205129
Birmingham, Alabama, United States
Medical Dermatology Specialist /ID# 205516
Phoenix, Arizona, United States
Arizona Research Center, Inc. /ID# 205795
Phoenix, Arizona, United States
The Dermatology Clinic of Arkansas /ID# 218749
Bryant, Arkansas, United States
Arkansas Research Trials /ID# 218469
North Little Rock, Arkansas, United States
Encino Research Center /ID# 207472
Encino, California, United States
University of California Irvine /ID# 205136
Irvine, California, United States
Ark Clinical Research /ID# 218193
Long Beach, California, United States
Keck School of Medicine of USC /ID# 206971
Los Angeles, California, United States
Wallace Medical Group /ID# 205701
Los Angeles, California, United States
Child Hosp of Orange County,CA /ID# 205735
Orange, California, United States
Palmtree Clinical Research Inc. /Id# 206184
Palm Springs, California, United States
Rady Children's Hospital San Diego /ID# 208244
San Diego, California, United States
Southern California Derma. Inc /ID# 205734
Santa Ana, California, United States
Innovative Clinical Research - Lafayette /ID# 208400
Lafayette, Colorado, United States
New England Research Associates, LLC /ID# 206896
Bridgeport, Connecticut, United States
Ideal Clinical Research Inc. /ID# 209880
Aventura, Florida, United States
Skin Care Research, LLC /ID# 207099
Boca Raton, Florida, United States
Midflorida Clinical Research, Inc. /ID# 213700
Brandon, Florida, United States
Clinical Research of West Florida, Inc /ID# 206146
Clearwater, Florida, United States
Revival Research /ID# 208383
Doral, Florida, United States
Universal Axon Clinical Research /ID# 213703
Doral, Florida, United States
Lakes Research, LLC /ID# 209156
Miami, Florida, United States
Miami Dade Medical Research Institute /ID# 209413
Miami, Florida, United States
Savin Medical Group, LLC /ID# 206902
Miami Lakes, Florida, United States
Floridian Clinical Research /ID# 207433
Miami Lakes, Florida, United States
Advanced Research for Health Improvement /ID# 217987
Naples, Florida, United States
Advanced Research for Health Improvement /ID# 218003
Naples, Florida, United States
Complete Health Research /ID# 213459
Ormond Beach, Florida, United States
Precision Clinical Research /ID# 207364
Sunrise, Florida, United States
Clinical Research Trials of Florida, Inc. /ID# 206840
Tampa, Florida, United States
ForCare Clinical Research /ID# 205120
Tampa, Florida, United States
Georgia Pollens Clinical Research Centers, Inc /ID# 218567
Albany, Georgia, United States
Marietta Dermatology Clinical Research /ID# 210317
Marietta, Georgia, United States
Agile Clinical Research Trials /ID# 218080
Sandy Springs, Georgia, United States
Treasure Valley Medical Research /ID# 210298
Boise, Idaho, United States
Great Lakes Clinical Trials /ID# 205830
Chicago, Illinois, United States
Ashira Dermatology /ID# 205512
Gurnee, Illinois, United States
Clinical Investigation Specialists, Inc. /ID# 206898
Gurnee, Illinois, United States
Northshore University Health System Dermatology Clinical Trials Unit /ID# 205135
Skokie, Illinois, United States
Raga Clinical Studies, LLC. /ID# 206749
Crown Point, Indiana, United States
Hutchinson Clinic /ID# 205970
Hutchinson, Kansas, United States
Continental Clinical Solutions /ID# 210327
Towson, Maryland, United States
Beacon Clinical Research, LLC /ID# 206894
Quincy, Massachusetts, United States
David Fivenson, MD, PLC /ID# 206903
Ann Arbor, Michigan, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 206895
Ann Arbor, Michigan, United States
Allergy, Asthma & Immunology Associates, PC /ID# 218169
Lincoln, Nebraska, United States
Skin Specialists, PC /ID# 205515
Omaha, Nebraska, United States
Duplicate_Summit Medical Group /ID# 213863
Clifton, New Jersey, United States
Skin Laser and Surgery Specialists of NY and NJ /ID# 206754
Hackensack, New Jersey, United States
Care Access Research /ID# 218476
Hoboken, New Jersey, United States
University of New Mexico School of Medicine /ID# 206756
Albuquerque, New Mexico, United States
Fordham Dermatology /ID# 218508
The Bronx, New York, United States
PMG Research of Wilmington LLC /ID# 205968
Wilmington, North Carolina, United States
University Hospitals Case Medical Center /ID# 206639
Cleveland, Ohio, United States
Awasty Research Network, LLC /ID# 206748
Marion, Ohio, United States
Southside Dermatology /ID# 214451
Tulsa, Oklahoma, United States
Vital Prospects Clinical Research Institute, PC /ID# 205824
Tulsa, Oklahoma, United States
Cyn3rgy Research /ID# 218064
Gresham, Oregon, United States
Velocity Clinical Research Hallandale Beach /ID# 207544
Medford, Oregon, United States
Clinical Research Solutions, LLC /ID# 218416
Jackson, Tennessee, United States
Stones River Dermatology /ID# 205178
Murfreesboro, Tennessee, United States
Metroplex Dermatology /ID# 213307
Arlington, Texas, United States
Bellaire Dermatology /ID# 205470
Bellaire, Texas, United States
Center for Clinical Studies /ID# 213186
Cypress, Texas, United States
Dermatology Treatment and Research Center, PA /ID# 205473
Dallas, Texas, United States
Epiphany Dermatology - Fort Worth /ID# 210073
Fort Worth, Texas, United States
Styde Research, LLC /ID# 213469
Lewisville, Texas, United States
Austin Institute for Clinical Research /ID# 206640
Pflugerville, Texas, United States
Derm Clin Res Ctr San Antonio /ID# 205469
San Antonio, Texas, United States
EPIC Medical Research /ID# 206382
Murray, Utah, United States
Aspen Clinical Research /ID# 208399
Orem, Utah, United States
Timber Lane Allergy & Asthma Research, LLC /ID# 206897
South Burlington, Vermont, United States
The Education & Research Foundation, Inc. /ID# 206900
Lynchburg, Virginia, United States
Bellingham Asthma Allergy and Immunology Clinic /ID# 210357
Bellingham, Washington, United States
Clinical Investigation Specialist, Inc - Kenosha /ID# 215933
Kenosha, Wisconsin, United States
The Skin Hospital /ID# 217846
Westmead, New South Wales, Australia
The Skin Centre /ID# 205922
Benowa, Queensland, Australia
Box Hill Hospital /ID# 206023
Box Hill, Victoria, Australia
Monash Children's Hospital /ID# 217917
Clayton, Victoria, Australia
Sinclair Dermatology /ID# 217791
East Melbourne, Victoria, Australia
The Royal Melbourne Hospital /ID# 205919
Parkville, Victoria, Australia
Murdoch Children's Research Institute /ID# 205667
Parkville, Victoria, Australia
Universitaetsklinikum St. Poelten /ID# 206909
Sankt Pölten, Lower Austria, Austria
Klinik Donaustadt /ID# 206572
Vienna, State of Vienna, Austria
Ordensklinikum Linz GmbH Elisabethinen /ID# 206573
Linz, Upper Austria, Austria
Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 208281
Salzburg, Austria
UCL Saint-Luc /ID# 205537
Woluwe-Saint-Lambert, Brussels Capital, Belgium
UZ Gent /ID# 205181
Ghent, Oost-Vlaanderen, Belgium
Centre Hospitalier Universitaire du Sart Tilman CHU de Liege /ID# 204938
Liège, Belgium
Medical center Sveti Panteleimon /ID# 210414
Sofia, Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD /ID# 205292
Sofia, Bulgaria
Military Medical Academy Multiprofile Hospital /ID# 205291
Sofia, Bulgaria
Medical complex Doverie /ID# 211289
Sofia, Bulgaria
Stratica Medical /ID# 205415
Edmonton, Alberta, Canada
Alberta DermaSurgery Centre /ID# 205422
Edmonton, Alberta, Canada
UBC Department of Dermatology and Skin Science The Skin Care Centre /ID# 207837
Vancouver, British Columbia, Canada
Pacific Derm /ID# 206797
Vancouver, British Columbia, Canada
Skin Care Studio /ID# 205420
St. John's, Newfoundland and Labrador, Canada
SimcoDerm Medical and Surgical Dermatology Center /ID# 206333
Barrie, Ontario, Canada