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Non-contrast DWI for Supplemental Screening
Sponsor: University of Washington
Summary
Diffusion-weighted imaging (DWI) is a short (under 5 minutes) non-contrast MRI technique that has shown promise for the detection and characterization of breast cancer. Our preliminary data has shown that DWI holds potential for detecting mammographically and clinically-occult breast cancers. However, current technical limitations reduce the sensitivity of DWI for screening applications. The identification of a screening tool to complement mammography that is more accurate than ultrasound and faster, less expensive, and safer than conventional contrast-enhanced MRI would have significant clinical impact by improving the early detection of cancer in women with dense breasts. We hypothesize that an optimized DWI approach will enable detection of mammographically occult breast cancer in women with dense breasts with high sensitivity and low false positive rate.
Official title: Non-contrast DWI for Supplemental Screening of Women With Dense Breasts
Key Details
Gender
FEMALE
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
269
Start Date
2018-07-16
Completion Date
2029-07
Last Updated
2025-10-09
Healthy Volunteers
Not specified
Conditions
Interventions
Non-contrast DWI
Diffusion-weighted imaging (DWI) is a non-contrast MRI technique that typically can be acquired in under 5 minutes. DWI reflects the microscopic cellular environment and can demonstrate differences between normal and malignant breast tissue without the aid of intravenous gadolinium.
Non-contrast MRI
Non-contrast MRI scans will include DWI along with anatomical T1-weighted and T2-weighted sequences.
Locations (2)
Oregon Health & Science University
Portland, Oregon, United States
Seattle Cancer Care Alliance
Seattle, Washington, United States