Clinical Research Directory

Inclusion Criteria: The investigators plan to include participants with Acute Ischemic Stroke, based on the TOAST classification : 1) large artery atherosclerosis (atherothrombotic), 2) cardioembolic, 3) small artery occlusion (lacunar), 4) stroke of undetermined etiology (ESUS). According to the TOAST classification, diagnoses are based on clinical presentation and on data collected by exams such as brain imaging (CT/MRI), cardiac imaging (echocardiography) and laboratory tests for the prothrombotic state. The diagnosis of Embolic Stroke of Undetermined Source (ESUS) was established based on the criteria defined by the Cryptogenic Stroke/ESUS International Working Group. Exclusion Criteria 1. presence of acute haemorrhagic stroke, 2. the presence of stroke of other determined etiology, 3. the history of previous Ischemic stroke and/or Myocardial Infarction (MI), 4. hypercoagulable state, 5. active malignancy 6. severe chronic kidney disease (eGFR\<30 ml/minute). These exclusion criteria are applied to both patients and control subjects.