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APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)
Sponsor: Wake Forest University Health Sciences
Summary
The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family, such as eye color or blood type. Variation in APOL1 can cause kidney disease. African Americans, Afro-Caribbeans, Hispanic Blacks, and Africans are more likely to have the APOL1 gene variants that cause kidney disease. APOLLO will test DNA from kidney donors and recipients of kidney transplants for APOL1 to determine effects on kidney transplant-related outcomes.
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
5000
Start Date
2019-03-21
Completion Date
2027-05-30
Last Updated
2025-12-15
Healthy Volunteers
No
Locations (18)
University of Alabama at Birmingham
Birmingham, Alabama, United States
University of California San Francisco
San Francisco, California, United States
University of Miami / Miami Transplant Institute
Miami, Florida, United States
Emory University School of Medicine
Atlanta, Georgia, United States
University of Maryland School of Medicine
Baltimore, Maryland, United States
Johns Hopkins University
Baltimore, Maryland, United States
Joslin Diabetes Center / Harvard University
Boston, Massachusetts, United States
University of Michigan Medicine
Ann Arbor, Michigan, United States
Saint Louis University Center for Transplantation
St Louis, Missouri, United States
Ichan School of Medicine at Mount Sinai
New York, New York, United States
Columbia University Irving Medical Center
New York, New York, United States
Weill Cornell Medicine
New York, New York, United States
Duke University
Durham, North Carolina, United States
Wake Forest School of Medicine
Winston-Salem, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
University of Wisconsin - Madison
Madison, Wisconsin, United States