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Diesel Exhaust Induces Glucocorticoid Resistance
Sponsor: University of British Columbia
Summary
The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication. One possible reason is that air pollution exposure may decrease the ability of corticosteroids to combat inflammation. To test this volunteers will inhale either a placebo or a corticosteroid, before sitting in an exposure booth for 2 hours breathing either filtered air or diluted diesel exhaust. Samples will be collected before and after exposure to analyze the effects of budesonide and diesel exhaust exposure.
Key Details
Gender
All
Age Range
19 Years - 49 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2018-12-01
Completion Date
2025-12-31
Last Updated
2024-07-24
Healthy Volunteers
No
Interventions
Placebo
Inhalation of air through a Turbuhaler that contains no medication, as a control.
Budesonide
1.6mg of budesonide from a Turbuhaler.
Filtered Air
Exposure to HEPA filtered air, as a control.
Diesel Exhaust
Diesel exhaust standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Locations (1)
University of British Columbia
Vancouver, British Columbia, Canada