Clinical Research Directory

Inclusion Criteria: * Adult patient with a score ASA between I and III * Patient scheduled for elective major abdominal surgery (by laparotomy) for cancer or diverticulosis * Patient that signed the consent form Exclusion Criteria: * \- Patient treated in emergency situation * Patient with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis) * Patient that needs a surgery for restoration of continuity * Patient pregnant, breastfeeding, or during periods of genital activity using no contraception. * Patient with contraindications to nefopam, morphine, or paracetamol * Patient with chronic obstructive pulmonary disease, renal or severe hepatic impairment * Patient under analgesics treatment * Patient who participated in a clinical study in the previous 6 months.