Clinical Research Directory

Inclusion Criteria: * Aged 18 - 50 years * Subject is willing to provide written informed consent and is able to comply with anticipated study procedures Exclusion Criteria: * Body Mass Index (BMI) \< 18.0 or \> 30.0 * Known significant respiratory, cardiovascular or medical condition that precludes study participation as judged by investigator * Anemia \[hemoglobin value below lower range of normal for gender\] * Abnormal hemoglobin electrophoresis result * Exposure to nicotine \[positive test at screening or study day\] * Abnormal drug screen \[positive test at screening or on day of study\] * Positive pregnancy test for females \[serum test at screening; urine test on study day\] * Abnormal Allen's test for collateral circulation * Abnormal Electrocardiogram * Abnormal Pulmonary Function Test * Abnormal venous blood gas result * Intolerance of facemask