Clinical Research Directory

Inclusion Criteria: 1. Willing and able to provide written informed consent 2. Age ≥ 18 years 3. Diagnostic coronary angiography or percutaneous coronary intervention via the transradial approach Exclusion Criteria: 1. Presence of a palpable hematoma or clinical concern of hemostasis at the transradial access site 2. Access or attempted access at a second site - including contralateral radial artery, brachial, or femoral artery or vein 3. Planned staged procedure, CABG or noncardiac surgery within 30 days 4. Contraindication or high risk of bleeding with anticoagulation 1. bleeding requiring medical attention in the previous 6 months 2. thrombocytopenia (platelets\<50 x 109/L) 3. prior intracranial hemorrhage 4. use of IIb/IIIa during percutaneous coronary intervention 5. administration of thrombolytic therapy in the preceding 24 hours 6. use of non-steroidal anti-inflammatory medications 7. ischemic stroke or transient ischemic attack diagnosed in the last 3 months 5. Cardiogenic shock 6. Ventricular arrhythmias refractory to treatment 7. Liver dysfunction (Child-Pugh class B or C) 8. Unexplained anemia with a Hgb below 100 g/L 9. History of medication noncompliance or risk factor for noncompliance 10. Active malignancy 11. Allergy to rivaroxaban 12. Another indication for anticoagulation 13. CYP3A4 and P-glycoprotein inhibitor use 14. Life expectancy \<30 days 15. Women capable of pregnancy not on birth control 16. Chronic kidney disease with creatinine clearance of less than 30mL/min 17. History of antiphosphopholipid antibody syndrome