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Study of Efficacy and Safety of Pembrolizumab Plus Platinum-based Doublet Chemotherapy With or Without Canakinumab in Previously Untreated Locally Advanced or Metastatic Non-squamous and Squamous NSCLC Subjects
Sponsor: Novartis Pharmaceuticals
Summary
This was a Phase III study of pembrolizumab plus platinum-based doublet chemotherapy with or without canakinumab in previously untreated locally advanced or metastatic non-squamous and squamous NSCLC participants.
Official title: A Randomized, Double-blind, Placebo-controlled, Phase III Study Evaluating the Efficacy and Safety of Pembrolizumab Plus Platinum-based Doublet Chemotherapy With or Without Canakinumab as First Line Therapy for Locally Advanced or Metastatic Non-squamous and Squamous Non-small Cell Lung Cancer Subjects (CANOPY-1)
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
673
Start Date
2018-12-21
Completion Date
2026-01-26
Last Updated
2026-06-17
Healthy Volunteers
No
Conditions
Interventions
canakinumab
canakinumab 200 mg subcutaneous (s.c.) injection every 3 weeks (squamous and non-squamous)
canakinumab-matching placebo
canakinumab placebo every 3 weeks (squamous and non-squamous)
pembrolizumab
200 mg every 3 weeks (squamous and non-squamous)
carboplatin
Area Under the Curve (AUC) 5 mg/mL\*min every 3 weeks (non-squamous) or AUC 6 mg/mL\*min (squamous)
cisplatin
75 mg/m\^2 every 3 weeks (non-squamous)
paclitaxel
200 mg/m\^2 every 3 weeks (squamous)
nab-paclitaxel
100 mg/m\^2 on Days 1, 8, and 15 of every cycle (squamous)
pemetrexed
500 mg/m\^2 every 3 weeks (non-squamous)
Locations (152)
Pacific Shores Medical Group
Long Beach, California, United States
USC Kenneth Norris Comprehensive Cancer Center
Los Angeles, California, United States
AdventHealth
Orlando, Florida, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Novartis Investigative Site
Caba, Buenos Aires, Argentina
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Caba, Argentina
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Westmead, New South Wales, Australia
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Wooloongabba, Queensland, Australia
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Melbourne, Victoria, Australia
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Murdoch, Western Australia, Australia
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Linz, Upper Austria, Austria
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Salzburg, Austria
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Barretos, São Paulo, Brazil
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São Paulo, São Paulo, Brazil
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São Paulo, São Paulo, Brazil
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Edmonton, Alberta, Canada
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Brampton, Ontario, Canada
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Toronto, Ontario, Canada
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Temuco, Araucania, Chile
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Santiago, Chile
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Harbin, Heilongjiang, China
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Wuhan, Hubei, China
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Wuhan, Hubei, China
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Changsha, Hunan, China
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Changchun, Jilin, China
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Xi’an, Shanxi, China
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Hangzhou, Zhejiang, China
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Beijing, China
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Valledupar, Cesar Department, Colombia
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Ostrava, Vitkovice, Czechia
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Brno, Czechia
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Brno, Czechia
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Prague, Czechia
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Herning, Denmark
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Oulu, Finland
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Marseille, Bouches Du Rhone, France
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Lyon, France
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Montpellier, France
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Nantes, France
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Paris, France
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Munich, Bavaria, Germany
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Göttingen, Lower Saxony, Germany
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Cologne, North Rhine-Westphalia, Germany
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Cologne, North Rhine-Westphalia, Germany
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Dresden, Saxony, Germany
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Leipzig, Saxony, Germany
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Halle, Saxony-Anhalt, Germany
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Berlin, Germany
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Essen, Germany
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Georgsmarienhütte, Germany
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Gerlingen, Germany
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Heidelberg, Germany
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Athens, GR, Greece
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Athens, Greece
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Kowloon, Hong Kong
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Veszprém, Hungary
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Reykjavik, Iceland
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Hyderabad, Andhra Pradesh, India
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Gurgaon, Haryana, India
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Pune, Maharashtra, India
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Jaipur, Rajasthan, India
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Hyderabad, Telangana, India
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Kolkata, West Bengal, India
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Avellino, AV, Italy
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Genova, GE, Italy
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Milan, MI, Italy
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Milan, MI, Italy
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Rozzano, MI, Italy
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Modena, MO, Italy
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Padova, PD, Italy
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Perugia, PG, Italy
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Parma, PR, Italy
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Orbassano, TO, Italy
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Milan, Italy
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Nagoya, Aichi-ken, Japan
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Sapporo, Hokkaido, Japan
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Himeji, Hyōgo, Japan
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Yokohama, Kanagawa, Japan
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Sakai, Osaka, Japan
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Sunto Gun, Shizuoka, Japan
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Chuo Ku, Tokyo, Japan
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Ube, Yamaguchi, Japan
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Osaka, Japan
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Beirut, Lebanon
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Saida, Lebanon
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Kuala Lumpur, Kuala Lumpur, Malaysia
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Kuantan, Pahang, Malaysia
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Kuching, Sarawak, Malaysia
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Kuala Lumpur, Malaysia
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Groningen, Netherlands
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Groningen, Netherlands
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Drammen, Norway
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City of Taguig, National Capital Region, Philippines
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Makati City, Philippines
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Quezon, Philippines
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San Juan City, Philippines
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Gliwice, Poland
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Poznan, Poland
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Tomaszw Mazowiecki, Poland
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Lisbon, Portugal
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Porto, Portugal
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Cluj-Napoca, Cluj, Romania
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Craiova, Dolj, Romania
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Arkhangelsk, Russia
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Omsk, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Singapore, Singapore
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Singapore, Singapore
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Singapore, Singapore
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Bratislava, Slovakia
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Kosice-Saca, Slovakia
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Gyeonggi-do, Korea, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Granada, Andalusia, Spain
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Badalona, Barcelona, Spain
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Donostia / San Sebastian, Gipuzkoa, Spain
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Las Palmas de Gran C, Las Palmas, Spain
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Barcelona, Spain
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Barcelona, Spain
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Madrid, Spain
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Madrid, Spain
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Madrid, Spain
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Madrid, Spain
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Málaga, Spain
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Valencia, Spain
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Zaragoza, Spain
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Stockholm, Sweden
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Basel, Switzerland
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Kaohsiung City, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Songkhla, Hat Yai, Thailand
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Khon Kaen, THA, Thailand
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Bangkok, Thailand
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Bangkok, Thailand
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Bangkok, Thailand
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Istanbul, Bagcilar, Turkey (Türkiye)
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Ankara, Bilkent Cankaya, Turkey (Türkiye)
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Edirne, Merkez, Turkey (Türkiye)
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Ankara, Sihhiye-Altindag, Turkey (Türkiye)
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High Heaton, Newcastle Upon Tyne, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Plymouth, United Kingdom
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Hanoi, Vietnam