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OCS™ Lung TOP Registry For Donor Lungs for Transplantation
Sponsor: TransMedics
Summary
Single-arm, prospective, multi-center, post-approval U.S. registry
Official title: The Organ Care System (OCS™) Lung Thoracic Organ Perfusion (TOP) Registry for Donor Lungs for Transplantation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
458
Start Date
2018-12-10
Completion Date
2029-11-30
Last Updated
2025-08-27
Healthy Volunteers
No
Conditions
Interventions
OCS Lung System
The OCS™ Lung System is a portable organ perfusion, ventilation, and monitoring medical device intended to preserve donor lungs in a near physiologic, ventilated, and perfused state prior to transplantation. This technology was designed to overcome the limitation of cold storage and has the potential to expand the utilization of donor lungs. The OCS™ Lung System accomplishes this by performing 3 key functions: * Reducing ischemic injury through the use of warm, oxygenated blood based perfusion. * Optimizing the lung condition by ventilatory recruitment maneuvers and high-oncotic perfusion solution supplemented with hormones and nutrients. * Allowing for ex-vivo functional assessment of the donor lung during preservation and prior to transplant.
Locations (18)
St. Joseph's Hospital and Medical Center
Phoenix, Arizona, United States
UCLA
Los Angeles, California, United States
Stanford University
Palo Alto, California, United States
UCSF
San Francisco, California, United States
Tampa General Hospital
Tampa, Florida, United States
Emory
Atlanta, Georgia, United States
University of Chicago
Chicago, Illinois, United States
Johns Hopkins
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
University of Minnesota
Minneapolis, Minnesota, United States
Nebraska Medical Center
Omaha, Nebraska, United States
Duke University
Durham, North Carolina, United States
Temple University
Philadelphia, Pennsylvania, United States
Baylor Scott & White Research Institute
Dallas, Texas, United States
Baylor St. Luke's Medical Center
Houston, Texas, United States
Houston Methodist
Houston, Texas, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States