Clinical Research Directory

Inclusion Criteria: * Male and female patients, age 18 to 80 years * Intensive care Unit (ICU) patients with septic shock (despite fluid resuscitation vasopressors needed to maintain mean arterial pressure ≥65 millimeter of mercury (mmHg), and serum lactate \>2mmol/l even with fluid application) * Treatment of septic shock on ICU with vasopressors not longer than 12 hours * Sedation and mechanical ventilation on ICU * Female patients of childbearing potential with negative pregnancy test * Informed Consent as documented by signature Exclusion Criteria: * Previous surgery and/or anesthesia (within last 7 days) * Application of nitric oxide (NO) * Suspected or known intolerance by history to volatile anesthetics (malignant hyperthermia) * Immunosuppressive agents * Systemic corticosteroids in the phase before hospitalization (\> 10mg/d prednisone) * Significant concomitant disease (acute cerebral vascular event, acute coronary syndrome, decompensated heart failure, acute pulmonary edema, major cardiac arrhythmia, seizure, burn, chronic kidney disease, end stage liver failure, neuromuscular disease) * AIDS * Autoimmune disease * Organ transplant * Subject with active malignancy receiving * chemotherapy or radiation treatment within last 60 days * Hepatitis B/C virus infection * Anti-tumor necrosis factor (TNF) therapy * Pregnancy and/or Breast feeding * Use of cytokine absorber * Enrollment in any other clinical trial during the course of this trial, 30 days prior to its beginning or 30 days after its completion