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GLUT1: A Novel Tool re fl Ecting Proliferative Activity of Lung Neuroendocrine Tumors
Sponsor: Centre Hospitalier Universitaire, Amiens
Summary
Lung neuroendocrine tumor (LNT) represents approximately 20% of all lung cancers. The classification of LNT relies upon morphology. Recently, in the World Health Organization (WHO) classification, Ki-67 rate has been proposed for classi fication. It is, however, known that Ki-67 count has a poor interlaboratory reproducibly. For that reason, our team has looked for a new biomarker. GLUT1 protein a facilitative glucose transporter protein which has ubiquitous expression in mammalian. GLUT1 is overexpressed in many human cancers. But, no study has evaluated the GLUT1 staining as an aid diagnosis in LNT. The team have assessed the GLUT1 immunohistochemical staining in 36 LNT and to assess its diagnostic value.
Official title: GLUT1: A Novel Tool Reflecting Proliferative Activity of Lung Neuroendocrine Tumors
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
36
Start Date
2014-01-01
Completion Date
2016-11-13
Last Updated
2026-06-17
Healthy Volunteers
No
Conditions
Interventions
Immunohistochemistry
Immunohistochemistry of Glut1 expression was performed in these 36 cases of neuroendocrine tumor.
Locations (1)
CHU Amiens-Picardie
Amiens, France