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Improving Infant Hydrocephalus Outcomes in Uganda
Sponsor: Boston Children's Hospital
Summary
Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative prognostic indicators of treatment response and long term outcomes.
Official title: Improving Infant Hydrocephalus Outcomes in Uganda: Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure After ETV/CPC
Key Details
Gender
All
Age Range
1 Day - 180 Days
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2021-05-05
Completion Date
2027-12
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Interventions
ETV/CPC
The Endoscopic Third Ventriculostomy/Choroid Plexus Cauterization (ETV/CPC) will comprise a standard frontal approach with flexible endoscopy.
Locations (3)
Penn State University
University Park, Pennsylvania, United States
The Hospital for Sick Children
Toronto, Ontario, Canada
Cure Children's Hospital of Uganda
Mbale, Uganda