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Comparison of Technics for Determination of Epstein-Barr Virus Serological Diagnosis
Sponsor: Centre Hospitalier Universitaire, Amiens
Summary
This study compared the performance of three automated immunoassays, Architect (Abbott), Immulite (Siemens) and Liaison (Diasorin), for Epstein-Barr virus (EBV) serology. Ninety-one serum samples collected in Amiens University Hospital were analyzed for the presence of Viral Capsid Antigen (VCA) IgG and IgM and Epstein-Barr Nuclear Antigen (EBNA) IgG. The agreement between the three assays was calculated for each marker individually and for determination of the EBV profile, based on interpretation of the combination of these three EBV markers.
Official title: Comparison of Abbott Architect®, Siemens Immulite®, and Diasorin Liaison® for Determination of Epstein-Barr Virus Serological Diagnosis
Key Details
Gender
All
Age Range
3 Years - 82 Years
Study Type
OBSERVATIONAL
Enrollment
91
Start Date
2015-01-01
Completion Date
2017-10-29
Last Updated
2026-06-16
Healthy Volunteers
No
Conditions
Interventions
Serological giagnosis
The serological diagnosis of EBV infection was performed in the Amiens University Hospital virology laboratory (France). 91 routinely collected samples were analyzed by Immulite, Architect, and Liaison Blood samples were centrifuged for 15 min at 2500g at room temperature. Sera were aliquoted and first analyzed by Immulite. All samples were tested for EBV VCA IgG, EBV VCA IgM and EBV EBNA IgG in order to determine infection status (primary EBV infection, past infection, absence of infection and indeterminate status).
Locations (1)
Amiens, France