Clinical Research Directory
Browse clinical research sites, groups, and studies.
Lassa Fever Clinical Course and Prognostic Factors in Nigeria
Sponsor: Alliance for International Medical Action
Summary
The investigators propose to conduct a nationwide (Nigeria), prospective, non-interventional cohort study describing the clinical course, biological characteristics, case management and outcomes in patients hospitalized for a suspected or confirmed diagnosis of Lassa fever in tertiary medical facilities situated in the most affected Nigerian states. Special focuses will be made on situations at risk of bad outcome such as pregnancies, acute kidney injury and electrolytic imbalance in patients with confirmed Lassa fever. Participants for which the diagnosis of Lassa fever will be finally excluded by reverse-transcriptase polymerase chain reaction (RT-PCR) will constitute the control group.
Official title: Observational Cohort Study of Lassa Fever Clinical Course and Prognostic Factors in an Epidemic Context in Nigeria
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
1200
Start Date
2018-04-05
Completion Date
2025-12-31
Last Updated
2025-01-29
Healthy Volunteers
No
Conditions
Interventions
Non interventional research
Participants are receiving the standard of care according to Nigerian Center for Disease Control (NCDC) Standard Operating Procedures for Lassa fever case management. This include the administration of intravenous ribavirin for Lassa confirmed cases as well as critically-ill Lassa suspected cases.
Locations (2)
Alex Ekwueme Federal University Teaching Hospital Abakaliki
Abakaliki, Ebonyi State, Nigeria
Owo Federal Medical Centre (Owo FMC)
Owo, Ondo State, Nigeria