Clinical Research Directory

Inclusion Criteria: * Patients of Emory Hand Surgeons undergoing surgery for an upper extremity fracture who are willing to participate in the study will be included in the study (Including American Orthopedic(AO) and American Orthopaedic Trauma Association (OTA) AO/OTA Classification 1, 2, and 7 +/- Type A, B, C). * Patients of Emory Hand Surgeons undergoing Total Shoulder Arthroplasty or Reverse Shoulder Arthroplasty who are willing to participate in the study will be included in the study (Walsh Classification A-D). * Patients of Emory Hand Surgeons undergoing surgery for upper extremity arthritis (ex. carpometacarpal arthroplasty) * Patients of Emory Hand Surgeons undergoing release for upper extremity compressive neuropathies (ex. carpal tunnel surgery) * Patients of Emory Hand Surgeons undergoing procedures for upper extremity tendon pathologies (ex. tendon repair) * Patients undergoing total hip arthroplasty for osteoarthritis of the hip * Patients undergoing total knee arthroplasty for osteoarthritis of the knee * Between the ages of 18 years and 95 years. * Patients willing and able to provide written and informed consent Exclusion Criteria: * Patients with concurrent and significant injuries to other bones or organs. * Patients with local infections. * Patients who are minors, vulnerable subjects, or who are not willing to consent to participate in the study. * History of alcohol or medical abuse, allergies to glucocorticoids, daily use of glucocorticoids or chronic opioid use prior to the injury (morphine, fentanyl, hydromorphone, ketobemidone, methadone, nico morphine, oxycodone, and meperidine), history of severe heart disease ( New York Heart Association (NYHA 2)), renal failure, or liver dysfunction, active peptic ulcer disease, diabetic neuropathy, rheumatoid arthritis, and neurological or psychiatric diseases, potentially influencing pain perception. * Women who are pregnant * Patients with pre-existing immune suppression, where further immune suppression with GCs could warrant unwarranted or unneeded risk. * Subjects who, in the opinion of the investigator, may be non-compliant with study schedules or procedures.