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Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients
Sponsor: KU Leuven
Summary
Critically ill patients usually develop hyperglycemia, which is associated with an increased risk of morbidity and mortality. Controversy exists on whether targeting normal blood glucose concentrations with insulin therapy, referred to as tight blood glucose control (TGC) improves outcome of these patients, as compared to tolerating hyperglycemia. It remains unknown whether TGC, when applied with optimal tools to avoid hypoglycemia, is beneficial in a context of withholding early parenteral nutrition. The TGC-fast study hypothesizes that TGC is beneficial in adult critically ill patients not receiving early parenteral nutrition, as compared to tolerating hyperglycemia.
Official title: Impact of Tight Blood Glucose Control Within Normal Fasting Ranges With Insulin Titration Prescribed by the Leuven Algorithm in Adult Critically Ill Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
9230
Start Date
2018-09-18
Completion Date
2026-11
Last Updated
2023-06-05
Healthy Volunteers
No
Conditions
Interventions
Insulin
When blood glucose exceeds the preset target, insulin will be administered through continuous intravenous infusion. Insulin will be titrated according to frequent measurement of blood glucose and with use of the LOGIC-insulin algorithm in the experimental group. The intervention will be stopped upon ICU discharge, or until the patient is able to resume oral feeding, or until the patient no longer has a central venous catheter, whatever comes first.
Locations (4)
Department of Intensive Care Medicine, University Hospital Ghent
Ghent, Belgium
Department of Intensive Care Medicine, Jessa Hospital Hasselt
Hasselt, Belgium
Department of Intensive Care Medicine, University Hospitals Leuven
Leuven, Belgium
Medical Intensive Care Unit, University Hospitals Leuven
Leuven, Belgium