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Postpartum Low-Dose Aspirin and Preeclampsia
Sponsor: Columbia University
Summary
The purpose of this research study is to find out whether women with severe preeclampsia taking low-dose aspirin (LDA) for 3 weeks post-delivery will experience an improvement in endothelial function (measured as flow-mediated dilation - FMD) and severity of disease, as the effects of preeclampsia can persist postpartum. Women diagnosed with severe preeclampsia prior to delivery will be enrolled and randomized to receive either low-dose aspirin (81mg) or placebo to take daily for up to 3 weeks post-delivery. Exploratory objective includes healthy control postpartum patients without preeclampsia and not on LDA during pregnancy or postpartum in comparison with the primary study population affected by preeclampsia with severe features.
Official title: Low-Dose Aspirin in the Postpartum Period and Endothelial Function in Patients With Preeclampsia
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2019-07-22
Completion Date
2026-12
Last Updated
2026-01-22
Healthy Volunteers
Yes
Conditions
Interventions
Aspirin tablet
Low dose aspirin, 81mg tablets, PO
Placebo oral capsule
Placebo oral capsule, PO
Locations (1)
Columbia University Irving Medical Center
New York, New York, United States