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Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia
Sponsor: Centre for Addiction and Mental Health
Summary
The object of this study to evaluation an Integrated Care Pathway (ICP) to treat Aggression and Agitation in Alzheimer's disease (AD-AA). The ICP is an algorithmic approach to use psychotropic medications and non-pharmacological interventions based on standardized assessments which fosters measurement-based decision making. This study will assess the efficacy of the ICP to treat AD-AA and its impact on inappropriate use of medications in inpatient settings and Long-Term Care Facilities (LTCF). The investigators will enroll and randomize 220 participants with AD-AA (110 inpatient and 110 LTCFs) to ICP vs. Treatment As Usual. Further, this study will also examine the impact of the ICP on caregiver burden and undertake a cost-effectiveness analysis of the ICP for patients with AD-AA.
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
187
Start Date
2018-11-01
Completion Date
2025-12-31
Last Updated
2025-02-28
Healthy Volunteers
No
Interventions
Non-Pharmacological Intervention
The behavioural intervention will be a structured implementation of individualized activities to be followed and customized as per the needs of the participant.
Pharmacological Intervention
The medication algorithm provides recommendations to the treatment team about algorithmic treatment and assessments as per the ICP but ultimately the decision to prescribe any particular intervention will be the treatment team's decision and the recommendations of the research team for ICP arm will not be binding for the treatment team.
Locations (6)
University of Calgary
Calgary, Alberta, Canada
Providence Care
Kingston, Ontario, Canada
LAWSON Health Research Institute
London, Ontario, Canada
Centre for Addiction and Mental Health
Toronto, Ontario, Canada
Ontario Shores Centre for Mental Health Sciences
Whitby, Ontario, Canada
Douglas Hospital Research Centre
Montreal, Quebec, Canada