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My Personalized Breast Screening
Sponsor: UNICANCER
Summary
MyPeBS is an international randomized, open-label, multicentric, study assessing the effectiveness of a risk-based breast cancer screening strategy (using clinical risk scores and polymorphisms) compared to standard screening (according to the current national guidelines in each participating country) in detecting stage 2 or higher breast cancers. Women will be differentially screened for 4 years and then, after an end-of-study mammogram, they will return to the routine screening practice. The main study endpoint will be measured at the end of the four years of intervention. Furthermore, follow up data will be collected for 15 years from study entry for evaluation of long-term cumulative breast cancer incidence and breast cancer-specific survival
Official title: International Randomized Study Comparing Personalized, Risk-Stratified to Standard Breast Cancer Screening In Women Aged 40-70
Key Details
Gender
FEMALE
Age Range
40 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
53142
Start Date
2019-07-18
Completion Date
2027-12-31
Last Updated
2025-09-18
Healthy Volunteers
Yes
Conditions
Interventions
Mammogram
Every 1-4 years according to the national/regional guidelines or personalised schedule according to risk assessment
Ultrasound
As required according to the national/regional guidelines or personalised schedule according to risk assessment
MRI
As required according to the national/regional guidelines or personalised schedule according to risk assessment
Tomosynthesis
As required according to the national/regional guidelines or personalised schedule according to risk assessment
Locations (6)
Institut Jules Bordet
Brussels, Belgium
Gustave roussy
Villejuif, France
Assuta Medical Center Ramat HaHayal
Tel Aviv, Israel
AUSL Reggio Emilia
Reggio Emilia, Emilia-Romagna, Italy
Marta Romản
Barcelona, Spain
Cambridge University Hospitals NHS Foundation Trust
Cambridge, Cambridgeshire, United Kingdom