Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib
Sponsor: Deciphera Pharmaceuticals, LLC
Summary
This is a 2-arm, randomized, open-label, international, multicenter study comparing the efficacy of ripretinib to sunitinib in GIST patients who progressed on or were intolerant to first-line anticancer treatment with imatinib. Approximately 426 patients will be randomized in a 1:1 ratio to ripretinib 150 mg once daily (continuous dosing for 6 week cycles) or sunitinib 50 mg once daily (6 week cycles, 4 weeks on, 2 weeks off).
Official title: A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of Ripretinib vs Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST) After Treatment With Imatinib
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
453
Start Date
2019-02-08
Completion Date
2026-12
Last Updated
2026-02-05
Healthy Volunteers
No
Conditions
Interventions
Ripretinib
Oral KIT/PDGFRA kinase inhibitor
Sunitinib
Oral receptor tyrosine kinase (RTK) inhibitor
Locations (121)
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
University of California San Diego Medical Center
La Jolla, California, United States
UCLA Hematology Oncology Center - Main Site
Los Angeles, California, United States
Stanford Medicine
Stanford, California, United States
University of Colorado Hospital - Anschutz Cancer Pavillion
Aurora, Colorado, United States
Rocky Mountain Cancer Centers
Denver, Colorado, United States
Smilow Cancer Hospital at Yale
New Haven, Connecticut, United States
Washington Cancer Institute at MedStar Washington Hospital Center
Washington D.C., District of Columbia, United States
Mayo Clinic Florida
Jacksonville, Florida, United States
Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Miami Cancer Institute at Baptist Health, Inc.
Miami, Florida, United States
Orlando Health UF Health Cancer Center
Orlando, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
Winship Cancer Institute
Atlanta, Georgia, United States
Georgia Cancer Specialists
Sandy Springs, Georgia, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
University of Chicago Medical Center
Chicago, Illinois, United States
IU Simon Cancer Center
Indianapolis, Indiana, United States
University of Iowa Hospital and Clinics
Iowa City, Iowa, United States
Norton Cancer Institute, Audubon Hospital Campus
Louisville, Kentucky, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
University of Minnesota Medical Center-Fairview
Minneapolis, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, United States
Rutgers Cancer Institute
New Brunswick, New Jersey, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
The Monter Cancer Center
Lake Success, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Montefiore Medical Center-Montefiore Medical Park
The Bronx, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Solove Research Institute
Columbus, Ohio, United States
University of Toledo
Toledo, Ohio, United States
Stephenson Cancer Center
Oklahoma City, Oklahoma, United States
Oregon Health & Science University Center for Health and Healing
Portland, Oregon, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States
Henry-Joyce Cancer Clinic
Nashville, Tennessee, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Virginia Commonwealth University Massey Cancer Center
Richmond, Virginia, United States
University of Washington Medical Center
Seattle, Washington, United States
Froedtert Hospital-Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Sanatorio Allende
Córdoba, Córdoba Province, Argentina
Instituto Medicao Especializado Alexander Fleming
Buenos Aires, Argentina
Border Medical Oncology Research Unit
Albury, New South Wales, Australia
Prince of Wales Hospital
Randwick, New South Wales, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Ashford Cancer Centre Research
Kurralta Park, South Australia, Australia
Ashford Cancer Centre Research
Kurralta Park, South Australia, Australia
The Alfred Hospital
Melbourne, Victoria, Australia
Princess Alexandara Hospital
Woolloongabba, Australia
Institut Jules Bordet
Brussels, Belgium
UZ Leuven
Leuven, Belgium
Cross Cancer Institute
Edmonton, Alberta, Canada
CancerCare Manitoba
Winnipeg, Manitoba, Canada
Juravinski Cancer Centre
Hamilton, Ontario, Canada
The Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Hopital Maisonneuve-Rosemont
Québec, Canada
Clinica San Carlos de Apoquindo Red Salud UC Christs
Santiago, Chile
Fakultni nemocnice v Motole
Prague, Czechia
Institut Bergonnié
Bordeaux, France
Centre Georges François Leclerc
Dijon, France
Centre Oscar Lambret
Lille, France
Centre Léon Bérard
Lyon, France
Hopital La Timone
Marseille, France
IPC
Marseille, France
IGR
Paris, France
CHU Poitiers-Hopital la Miletrie
Poitiers, France
ICO - Site René Gauducheau
Saint-Herblain, France
HELIOS Klinikum Berlin-Buch
Berlin, Germany
Technische Universitat Dresden
Dresden, Germany
West German Cancer Center
Essen, Germany
Magyar Honvedseg Egeszsegugyi Kozpont
Budapest, Hungary
Debreceni Egyetem
Debrecen, Hungary
Shamir Medical Center (Assaf Harofeh)
Be’er Ya‘aqov, Israel
Rabin Medical Cente
Petah Tikva, Israel
Tel-Aviv Sourasky Medical Center
Tel Aviv, Israel
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi
Bologna, Italy
stituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori
Meldola, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
IOV - Istituto Oncologico Veneto IRCCS
Padova, Italy
Universita degli Studi di Palermo
Palermo, Italy
Università Campus Bio-Medico di Roma
Rome, Italy
Antoni van Leeuwenhoek
Amsterdam, Netherlands
The Netherlands Cancer Institute
Amsterdam, Netherlands
University Medical Center Groningen
Groningen, Netherlands
Leiden University Medical Centre
Leiden, Netherlands
Oslo University Hospital
Oslo, Norway
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie
Warsaw, Poland
National Cancer Centre
Singapore, Singapore
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Ajou University Hospital
Suwon, South Korea
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital de Basurto
Bilbao, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Clinico San Carlos
Madrid, Spain
Hospital Universitario HM Madrid Sanchinarro
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario Ramon y Cajal
Madrid, Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, Spain
Hospital Universitario Virgen del Rocio
Seville, Spain
Instituto Valenciano de Oncología,
Valencia, Spain
Complejo Hospitalario Universitario de Vigo
Vigo, Spain
Karolinska universitetssjukhuset
Solna, Sweden
Centre Hospitalier Universitaire Vaudois, Fondation du Centre Pluridisciplinaire d'Oncologi
Lausanne, Switzerland
Universitaetsspital Zuerich, Klinik fuer Onkologie
Zurich, Switzerland
Chang Gung Memorial Hospital
Linkou District, Taoyuan County, Taiwan
Kaohsiung Chang Gung Memorial Hospital,
Kaohsiung City, Taiwan
China Medical University Hospital
Taichung, Taiwan
National Chen Kung University Hospital
Tainan, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
St James's University Hospital
Leeds, United Kingdom
Royal Marsden Hospital - Fulham
London, United Kingdom
University College London Hospitals
London, United Kingdom
Weston Park Hospital
Sheffield, United Kingdom