Clinical Research Directory

Inclusion Criteria: 1. Histologically confirmed patients with primary hepatocellular carcinoma, HKLC Stage IIa. 2. Age is greater than 18 years old, male or female. 3. The tumor size is 3cm-5cm, and the lesions are \<3. 4. ECOG score \< 2, Child-Pugh classification A or B. 5. The participants freely sign informed consent; Exclusion Criteria: 1. Pregnant or breast-feeding; psychiatric problems, addiction, or any other disorder that prevented informed consent; 2. Portal vein thrombosis or extrahepatic metastases; 3. White blood cell count \<2 x 10e9/L, platelet count \<40 x 10e9/L, serum creatinine \>110 mol/L, aspartate aminotransferase \>3 times upper limit, serum bilirubin \> 2.5 times upper limit, prothrombin time\> 19 seconds. 4. Active uncontrolled infection; 5. Concurrent systemic corticosteroid treatment 6. Primary immunodeficiency or systemic autoimmune disease; being treated with immunosuppressive drugs for other diseases; 7. Clinically significant ischemic heart disease or cardiac failure; 8. The investigator believes that there are other reasons that are not suitable for inclusion.