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Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
Sponsor: University of British Columbia
Summary
The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER waitlist activation is not inferior to regular (i.e., annual) screening for CAD during wait-listing for the prevention of Major Adverse Cardiac Events. Secondary analyses will assess the impact of screening on the rate of transplantation, and the relative cost-effectiveness of screening.
Official title: Canadian-Australasian Randomised Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3306
Start Date
2018-12-01
Completion Date
2025-12-31
Last Updated
2024-05-13
Healthy Volunteers
No
Conditions
Interventions
No screening
No further screening for asymptomatic coronary artery disease after wait-list entry
Regular Screening
Annual or second-yearly screening for asymptomatic coronary artery disease after wait-list entry
Locations (22)
University of Arizona
Tucson, Arizona, United States
The George Washington University
Washington D.C., District of Columbia, United States
University of Alberta
Edmonton, Alberta, Canada
University of British Columbia
Vancouver, British Columbia, Canada
Dalhousie University
Halifax, Nova Scotia, Canada
St. Joseph's Healthcare
Hamilton, Ontario, Canada
Kingston Health Science Centre
Kingston, Ontario, Canada
London Health Science Centre
London, Ontario, Canada
The Ottawa Hospital Research Institute
Ottawa, Ontario, Canada
University Health Network
Toronto, Ontario, Canada
St Michael's Hospital
Toronto, Ontario, Canada
CHU de Quebec-Universite Laval's L'Hotel-Dieu de Quebec
Laval, Quebec, Canada
University of Montreal, Maisonneuve-Rosemont Hospital
Montreal, Quebec, Canada
McGill University Health Centre
Montreal, Quebec, Canada
Universite de Montreal, Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada
St. Paul's Hospital, University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Charité Universitätsmedizin
Berlin, Germany
Sussex Brighton R&D
Brighton, United Kingdom
King's College Hospital NHS Foundation Trust
Brixton, United Kingdom
Epsom and St Helier University Hospitals NHS Trust
Carshalton, United Kingdom
Barts Health NHS Trust
London, United Kingdom
St George's University Hospital NHS Trust Foundation
London, United Kingdom